期刊文献+

HIV感染症状长期不进展者NK细胞变化研究 被引量:5

Study on natural killer cells in HIV long-term nonprogressors
原文传递
导出
摘要 目的探讨HIV长期不进展者NK细胞的变化。方法应用流式细胞术对HIV长期不进展者、典型进展者和HIV抗体阴性正常对照外周血NK细胞、NKT细胞及NK细胞趋化因子受体等进行研究。结果长期不进展者NKT细胞绝对计数与正常对照差异无统计学意义(P=0.301),高于HIV感染者和艾滋病病人(P=0.01,P=0.002);长期不进展者NK细胞绝对计数低于正常对照(P=0.03),高于HIV感染者和艾滋病病人(P=0.005,P<0.0001);长期不进展者NK细胞与CD4+T淋巴细胞呈正相关(r=0.393,P=0.001);NKT细胞与CD8+T淋巴细胞呈正相关(r=0.372,P=0.002)。长期不进展者NK细胞表达的CCR5受体低于典型进展者和正常对照(P<0.01)。结论NK细胞的变化与HIV疾病进展相关,值得深入研究。 Objective To study the changes of natural killer cells in HIV long-term nonprogressors. Methods NK cells, NKT cells and the expression of coreceptors on NK cells were examined in HIV long-term nonprogressors, typical progressors and normal controls with flow cytometer. Results The absolute count of NKT cells in HIV long-term nonprogressors showed no difference as comparing to normal controls(P=0.301), but was higher than that of HIV infection and AIDS patients(P=0.01, P=0.002); the absolute count of NK cells in long-term nonprogresors was lower than that of normal controls(P=0.03) and higher than that of HIV infection and AIDS patients (P=0.005, P<0.0001); the NK cells was positively related to CD4+ T cells(r=0.393, P=0.001) and NKT cells was positively related to CD8+ T cells(r=0.372, P=0.002). The expression of CCR5 on NK cells in HIV long-term nonprogressors was lower than that of HIV/AIDS patients(P<0.05); and there was no significant difference between HIV long-term nonprogressors and seronegative controls(P=0.05). Conclusion The changes of NK cells is related to HIV disease progression.
出处 《中华微生物学和免疫学杂志》 CAS CSCD 北大核心 2005年第6期452-456,共5页 Chinese Journal of Microbiology and Immunology
基金 国家自然科学基金(No.30471548) 国家"十五"科技攻关课题资助(2004BA719A12)
  • 相关文献

参考文献14

  • 1Hogan CM, Hammet SC. Host determinants in HIV infection and disease. Annal Intern Med, 2001, 134(9): 761-776.
  • 2Miller J. The biology of natural killer cells in cancer, infection and pregnancy. Exper Hematol, 2001, 29: 1157-1168.
  • 3Doherty DG, Norris S, Madrigal-Estebas L, et al. The human liver contains multiple populations of NK cells, T cells, and CD3+CD56+ natural T cells with distinct cytotoxic activities and Th1, Th2, and Th0 cytokine secretion patterns. J Immunol, 1999, 163: 2314-2321.
  • 4Franitza S, Grabovsky V, Wald O, et al. Differential usage of VLA-4 and CXCR4 by CD3+CD56+ NKT cells and CD56+CD16+ NK cells regulates their interaction with endothelial cells. Eur J Immunol, 2004, 34: 1333-1341.
  • 5Dalod M, Dupuis M, Deschemin JC, et al. Broad, intense anti-human immunodeficiency virus ( HIV) ex vivo CD8+ responses in HIV type 1-infected patients: comparison with anti-Epstein-Barr virus responses and changes during antiretroviral therapy. J Virol, 1999, 73: 7108-7116.
  • 6Mulherin SA, O′Brien TR, Ioannidis JP, et al. Effect of CCR5-Δ32 and CCR2-64I alleles on HIV-1 disease progression: the protection varies with duration of infection. AIDS, 2003, 17(3): 377-387.
  • 7Ioannidis JP, Contopoulos-Ioannidis DG, Rosenberg PS, et al. Effect of CCR5-Δ32 and CCR2-64I alleles on disease progression of perinatally HIV-1-infected children: an international meta-analysis. AIDS, 2003, 17(11): 1631-1638.
  • 8Migueles SA, Laborico AC, Imamichi H, et al. The differential ability of HLA B·5701+ long-term nonprogressors and progressors to restrict of autologous viral gag sequences. J Virol, 2003, 77(12): 6889-6898.
  • 9Lum JJ, Cohen OJ, Nie Z, et al. Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis. J Clin Invest, 2003, 111(10): 1547-1554.
  • 10Wang B, Mikhail M, Dyer WB, et al. First demonstration of a lack of viral sequence evolution in a nonprogression, defining replication-incompetent HIV-1 infection. Virol, 2003, 312(1): 135-150.

同被引文献77

引证文献5

二级引证文献8

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部