摘要
本文采用荧光偏振免疫分析法测定１２例新生儿血中茶碱浓度，氨茶碱剂量按５ｍｇ／ｋｇ恒速静脉滴注。经时采样，测得数据，经分析药时曲线拟合呈一室模型，平均清除速度常数０．０３７±０．００８ｈ￣（－１），平均消除半衰期１９±４ｈ，平均表观分布容积０．８２±０．１４Ｌ／ｋｇ，平均清除率３０±５ｍｌ／（ｈ·ｋｇ）。消除半衰期最大相差２．１倍，显示明显个体差异。
Liang Wenquan (Zhejiang Medical University ,Hangzhou 310006)Twelve
neonates were given with aminophylline 5mg/kg by constant infusion.The serum concentration
oftheophylline was determined by fluorescence polarization immunoassay.Theophylline
showed one compartmentmodel,the values of Ke,T_(1'2),Vd and Cl were 0. 037±0.008h￣(-,19
±4h,0.82±0. 14L/kg and 30±5ml/(h·kg) respectively.The maximum differancein elimination
half- life was 2.1 times. It suggested significant individualdifference.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1995年第12期534-536,共3页
Chinese Journal of Hospital Pharmacy
关键词
氨茶碱
药物动力学
新生儿
theophylline,pharmacokinetics ,neonate
