摘要
目的观察降酶口服液对D-氨基半乳糖所致肝损伤的保护作用。方法动物随机分为空白对照组、模型对照组、阳性药对照组和高、低剂量给药组,连续给药5d后腹腔注射D-氨基半乳糖800mg·kg-1,观察40h后给予D-氨基半乳糖各组的肝脏指数、血清ALT、AST及病理组织学的变化,比较组间差异的显著性。结果与模型组相比用药各组的肝脏指数较低,血清转氨酶升高不明显,病理学显示用药各组的肝细胞变性、坏死明显轻于模型对照组。结论降酶口服液能阻止D-氨基半乳糖造成的肝脏指数增加,降低转氨酶,减轻肝脏病理损害,对实验性急性肝损伤有明显保护作用。
Objective To study the protective effect of Jiangmei Koufuye(JMKFY)on acute liver injury which was induced by D-galactosamin(GalN).Methods The mice were randomly divided into five groups,which were given Hugan Capsules,JMKFY(high dose,low dose)and normal saline respectively for 5 days.Then D-GalN was injected into the abdomind of all of the mice.Liver index,serum ALT、AST and hepatic,histopathologic examination in each group were observed after 40 hours.Results Liver index and changes of serum ALT、AST in the treated groups were lower than that in the control group.Hepatic histopathologic examination showed that hepatocyte degeneration and necrosis attenuated more obvious compared the control group.Conclusion JMKFY can prevent liver index,decrease transaminase,relieve heptic histopathologic injury.It has significant protective effect on acute live injury induced by D-GalN.
出处
《齐鲁药事》
2005年第7期435-436,共2页
qilu pharmaceutical affairs
