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胰淀素与代谢综合征 被引量：2

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摘要 胰淀素是同胰岛素一起由胰岛β细胞分泌的肽类激素。近来发现它具有抑制餐后胰升糖素分泌、延缓胃排空、降低餐后血糖过度波动、增高糖尿病患者血糖达标率而不增加低血糖发生率,同时减少胰岛素用量、减轻体重、抑制食欲、减少体脂、舒张血管、降低餐后血中甘油三酯漂移等作用,是反映体内脂肪储存的信号之一,可调节机体长期能量平衡,与代谢综合征密切相关。
作者 黄志宏 高燕燕
机构地区 山东大学山东省立医院内分泌科
出处 《国外医学（内分泌学分册）》 2005年第4期246-248,共3页 Foreign Medical Sciences(Section of Endocrinology)
基金 济南市医学科技发展专项基金资助项目(200320)
关键词 胰淀素 代谢综合征 胰岛Β细胞分泌 肽类激素 糖尿病
分类号 R589 [医药卫生—内分泌]
  • 相关文献

参考文献22

  • 1Beales IL, Calam J. Regulation of amylin release from cultured rabbit gastric fundic mucosal cells. BMC Physiol,2003,3:13.
  • 2Ratner RE, Dickey R, Fineman M, et aI. Amylin replacement with pramlintide as an adjunct to insulin therapy improves long-term glycaemic and weight control in type 1 diabetes mellitus: a 1-year, randomized controlled trial. Diabet Med,2004,21:1204-1212.
  • 3Maggs DG, Fineman M, Kornstein J, et al. Pramlintide reduces postprandial glucose excursions when added to insulin lispro in subjects with type 2 diabetes: a dose-timing study. Diabetes Metab Res Rev,2004,20:55-60.
  • 4Levetan C, Want LL, Weyer C, et al. Impact of pramlintide on glucose fluctuations and postprandial glucose, gulcagon, and triglyceride excursions among patients with type 1 diabetes intensively treated with insulin pumps. Diabetes Care,2003,26:1-8.
  • 5Fineman M, Weyer C, Maggs DG, et al. The human amylin analog,pramlintide, reduces postprandial hyperglucagonemia in patients with type 2 diabetes mellitus. Horm Metab Res,2002,34:504-508.
  • 6Fineman MS, Koda JE, Shen LZ, et al. The human amylin analog,pramlintide, corrects postprandial hyperglucagonemia in patients with type 1 diabetes. Metabolism,2002,51:636-641.
  • 7Heise T, Heinemann L, Heller S, et al. Effect of pramlintide on symptom, catecholamine, and glucagon responses to hypoglycemia in healthy subjects. Metabolism,2004,53:1227-1232.
  • 8Buse JB, Weyer C, Maggs DG. Amylin replacement with pramlintide in type 1 and type 2 diabetes. Clin Diabet,2002,20:137-144.
  • 9Vella A, Lee JS, Camilleri M, et al. Effects of pramlintide, an amylin analogue, on gastric emptying in type 1 and 2 diabetes mellitus. Neurogasreoenterol Motil, 2002,14:123-131.
  • 10Rushing PA. Central amylin signaling and the regulation of energy homeostasis. Curr Pharm Des, 2003,9: 819-825.

同被引文献31

  • 1付方明,李利平,董砚虎.胰淀素研究新进展[J].国外医学（内科学分册）,2004,31(5):191-193. 被引量：4
  • 2王银霞,朱铁虹.胰淀素与2型糖尿病[J].国外医学（内分泌学分册）,2005,25(1):27-29. 被引量：1
  • 3金文胜,潘长玉.国际糖尿病联盟关于代谢综合征定义的全球共识[J].中华内分泌代谢杂志,2005,21(4):412-413. 被引量：157
  • 4林毅,彭永德.胰淀素类似物普兰林肽[J].世界临床药物,2006,27(11):673-676. 被引量：3
  • 5蔡乐,朱珠,王强,刘新月.胰岛素类似物与新型降糖激素类药物[J].中国新药杂志,2007,16(6):432-437. 被引量：26
  • 6Ryan G,Briscoe TA,Jobe L.Review of pramlinfide as adjunctive therapy in treatment of typel and type2 diabetes[J].Drug Design Development and Therapy,2008,2(1):203-214.
  • 7Vlieghe P, Lisowski V, Martinez J,et al.Synthetic therapeutic peptides:science and market[J]. Drug Discorvery Today,2010,15( 1 ):40-56.
  • 8Fineman M,Weyer C,Maggs DG,et al.The human amylin analogue,pramlintide,reduces postprandial hyperglucagonemia in patients with type 2 diabetes mellitus[J].Horm Metab Res,2002,3(4): 504-508.
  • 9Levetan C,Want LL,Weyer C,et al.Impact of pramlintide on glucose fluctuations and postprandial glucose, and triglyceride excursions anaong patients with type 1 diabetes intensively treated with insulin pumps[J].Diabetes Care,2003,2(6): 1-8.
  • 10Fineman MS,Koda JE,Shen LZ,et al.The human amylin anaiogue,pramlintide,corrects postprandial hyperglucagonemia in patients with type 1 diabetes[J].Metabosim,2002,51(5):636-641.

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国外医学（内分泌学分册）
2005年 第4期

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