摘要
目的探讨药敏试验在膀胱灌注预防肿瘤复发中的价值。方法将68例浅表性膀胱癌患者随机分为两组,药敏组32例,对照组36例,两组患者均行保留膀胱手术。将药敏组的手术标本进行药敏试验,根据结果选择最敏感的一种化疗药物进行膀胱灌注,对照组根据经验应用化疗药物灌注,随访10～28个月。结果所有患者均获得随访。药敏组复发3例,复发率9.4%;对照组复发8例,复发率22.2%。两组相比差异有显著性意义(P<0.05)。结论肿瘤药敏试验能客观地指导临床医生选择化疗药物,有效地提高膀胱灌注的疗效。
ObjectiveTo evaluate the effect of drug sensitivity test for the prevention of recurrence of bladder cancer. MethodsSixty eight patients with superficial bladder cancer after TURBt or partial cystectomy were divided into two groups randomly: drug sensitivity group 32 cases received intravesical instillation according the results of drug sensitivity test; control group 36 cases were given intravesical instillation basing on the experience of doctors.All the patients were followed up for 10 to 28 months.ResultsRecurrence rate was 9.4 %(3/32) in drug sensitivity group and 22.2 %(8/36) in control group.The difference was significant.ConclusionDrug sensitivity test can direct the choice of drugs for intravesical instillation objectively and improve the efficiency of treatment of bladder cancer effectively.
出处
《河北医科大学学报》
CAS
2005年第4期256-258,共3页
Journal of Hebei Medical University
关键词
膀胱肿瘤
灌注
局部
药物筛选试验
抗肿瘤
bladder neoplasms
perfusion,regional
durg screening assays,antitumor
