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MAPKs信号转导在类风湿关节炎滑膜细胞中作用及其药物的影响 被引量:1

Function of MAPKs signal transduction in synoviocytes with rheumatoid arthritis and the effect of drugs
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摘要 MAPKs信号转导途径的活化是RA慢性滑膜炎的典型特征,通过这一途径诱导滑膜细胞胞浆蛋白磷酸化,进而使转录因子和核蛋白如cfos、cjun、AP1和NFκB等磷酸化,从而促进细胞增殖和活化。上述机制研究对于RA发病机制的深入了解以及研制开发治疗类风湿关节炎的新型药物具有重要的意义。 The activation of MAPKs signal transduction parthways, is a typical feature of chronic synovitis in rheumatoid arthritis. The phosphorylation of synoviocytes cytoplasm proteins induced transcription factor and nucleus proteins phosphorylation such as c-fos, c-jun, AP-1 and NF-κB via MAPKs signal transduction, which promotes synoviocytes proliferation and activation. These findings may be beneficial for the elucidation of the pathogenesis and the development of new drugs for rheumatoid arthritis.
出处 《中国药理学通报》 CAS CSCD 北大核心 2005年第7期773-777,共5页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No30271606) 安徽省自然科学基金资助项目(No00044411)
关键词 MAPKS 类风湿关节炎(RA) 滑膜细胞 药物治疗 MAPKs rheumatoid arthritis(RA) synoviocytes drug treatment
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