摘要
我们采用第二代EIA法检测了82例再生障碍性贫血(AA)患者血清丙型肝炎病毒抗体(抗HCV),结果显示,输血治疗的AA患者抗HCV阳性率69.4%(43/62),显著高于未输血患者(p<0.01),慢性AA与急性AA抗HCV阳性率无明显差别(P>0.05)。AA患者输血后丙型肝炎(PTHC)发生率33.9%(21/62),其中急性AA68.8%(11/16),慢性AA21.7%(10/46),前者显著高于后者(P<0.01)。抗HCV阳性患者发生PTHC组与未发生PTHC组输血量、血红蛋白水平、白细胞数的差别无统计学意义。抗HCV阳性患者AA有效率明显低于抗HCV阴性患者(p<0.05)。AA患者发生PTHC以急性、黄疸型多见,合并PTHC后易出血、感染。本研究结果表明,PTHC已成为AA的重要合并症,AA合并PTHC采用中西医结合治疗可取得较好疗效。
The testing kit of second generation for serum anti-HCV was used in 82 cases of aplastic anemia(AA).The results showed that positive rate was 69.4%(43/62) in the patients of AA with transfusion,this was significantly higher than that in the patients of AA without transfusion.There was no difference of anti-HCV antibody positive rate between chronic AA and acute AA(P>0.05),incidence rate of post-transfusion hepatitis C(PTHC) in AA was 33.9%(21/62),among which the incidence rate in acute and chronic AA were 68.8%(11/16) and 21.7%(10/46) respectively(P<0.01).The anti-HCV positive patients were divided into two groups:PTHC and non-PTHC,there was no statistical difference of their transfusion volume,hemoglobin, white blood cell between these groups.Response rate of AA was lower in anti-HCV positive patients than that in negative patients(P<0.05).Acute,icteric PTHC was predominant in patients with AA.The patients with AA complicated with PTHC was liable to bleed and be infected.PTHC has been an importent complication in patients with AA.The better response was obtained by TCM-WM therapy in the patients.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1995年第4期198-201,共4页
Chinese Journal of Integrated Traditional and Western Medicine