摘要
以硫酸氢黄连素与ＰＶＰ之比为１：５制成共沉淀物，采用药脂比为１：２０、胆固醇与豆磷脂之比为２：７制备硫酸氢黄连素脂质体，包封率为４８．７２％。经大鼠在体小肠吸收试验表明：脂质体与游离药物相比，增加吸收值４倍多。
The co-precipitate has been made from
berberine bisulfate and polyvingl pyrrolidone (PVP) with theratio of
1 : 5. The liposomes entrapped berberine bisulfate have been prepared
with the ration of drug to lipid 1 : 20and the ratio of cholesterol
to soy phosphatide 2 : 7. The percentage of encapsulation is 48. 72%.
The test in vivo ofsmall intestinal absorption in rats shows that
liposomes can increase the abserption by 4-fold odd compared with
freeber-berine bisulfate.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1995年第12期730-731,共2页
China Journal of Chinese Materia Medica
基金
江苏省科委资助
关键词
硫酸氢黄连素
脂质体
小肠吸收
研制
berberine bisulfate
liposomes
small intestinal absorption
