摘要
人类免疫缺陷病毒(Human Immunodeficiency Virus,简称HIV)是导致艾滋病的病原体。研究HIV的病原学是认识HIV的致病机理、寻找有效的抗病毒治疗的靶位、设计HIV疫苗和诊断方法并最终控制艾滋病的基础。自从1983年HIV被分离出以来,HIV的病原学研究取得了长足进展:阐明了HIV的形态、结构以及病毒各个组成部分的功能;了解了HIV的复制和生命周期,并对病毒复制的调控有了基本的认识;对HIV在体内的动态和变异规律有了深入的了解;在上述认识的基础上,对HIV的致病机理以及病毒与宿主细胞的相互作用进行了深入的研究并取得了良好的进展。但是,艾滋病的抗病毒治疗和特异性免疫预防还远没有解决。开展深入的艾滋病病原学和致病机理研究,进一步揭示病毒复制、调控和致病的分子机制,阐明病毒与宿主细胞的相互作用,是发展新型抗药物、设计有效的HIV疫苗的前提和保证。本文概括了HIV病原学研究领域的主要进展,并提出了今后研究的展望。
Human Immunodeficiency Virus (HIV) is the pathogen of AIDS. Research on HIV etiology is the basis of understanding HIV pathogenesis, searching for the targets of antiretroviral therapy, designing of effective HIV vaccine and diagnostic methods. Since HIV was isolated in 1983, the biology study has made great progress. The shape, structure and function of each ingredient of the viral particle have been clarified. The replication and life cycle of the virus have been understood, the control and regulation of virus replication have been revealed. The dynamic and variation of the virus have been comprehended. On the basis of the these knowledge, the pathogenesis of HIV and the interaction between HIV and host cell have been bright to light. However, HIV antiretroviral therapy and specific immune prevention are still great problems, the advanced research on HIV biology and pathogenesis is urgently needed for revealing molecular mechanism of HIV replication, regulation and pathogenesis, clarifying the interaction between HIV and host cell and development of new antiretroviral agents and vaccine.
出处
《科技导报》
CAS
CSCD
2005年第7期9-16,共8页
Science & Technology Review
