摘要
目的:研究苯丁酸钠(PB)与诱导化疗药物对体外喉癌Hep2细胞株的联合作用,探讨PB对喉癌诱导化疗的影响。方法:采用四甲基偶氮唑蓝法(MTT)检测PB分别与5氟脲嘧啶(5FU)和顺铂(CDDP)联合作用时对喉癌细胞的生长抑制作用。结果:5FU和CDDP分别与PB联合应用时,两药各个剂量组与对照组比较及各个剂量组之间比较,差异均有统计学意义(均P<0.05);当5FU和CDDP的浓度一定时,PB的各个剂量组之间比较差异均有统计学意义(均P<0.05)。结论:PB能增强诱导化疗药物对体外喉癌细胞的细胞毒作用,为临床增强喉癌诱导化疗的疗效,减少并发症和毒性反应的发生提供了新的思路。
Objective:To study the effect of sodium phenylbutyrate when it combined with agents used in induction chemotherapy on laryngeal carcinoma cells Hep-2 in vitro.Method:MTT were used to examine the growth inhibition of Hep-2 cells treated by the combination of PB with 5-FU or CDDP in vitro.Result:When 5-FU or CDDP combined with PB respectively,there was significantly difference between every two dose groups of the two agents or every dose group and control group(P<0.05).When the dosage of 5-FU or CDDP was definition,there was significantly difference between every two dose groups of PB(P<0.05).Conclusion:PB could enhance the cytotoxic effects of agents used in induction chemotherapy on laryngeal carcinoma cells Hep-2 in vitro, which showed the possibility in reinforcement the treatment effect and reduction the occurence of the complication and toxic reaction of induction chemotherapy on laryngeal carcinoma.
出处
《临床耳鼻咽喉科杂志》
CSCD
北大核心
2005年第15期680-682,共3页
Journal of Clinical Otorhinolaryngology
关键词
苯丁酸钠
喉肿瘤
诱导化疗
5-氟脲嘧啶
顺铂
Sodium phenylbutyrate
Laryngeal neoplasms
Induction chemotherapy
5-Flucytosine
Cisplatin
