摘要
目的:分析甲状腺功能亢进症患者骨密度及骨代谢指标的改变,并与健康对照组比较。方法:采用双能X射线吸收法对2003-01/11青岛市海慈医院内分泌门诊及住院的73例甲状腺功能亢进患者和与患者年龄、性别及月经状况相匹配的73名健康对照者进行L2～4椎体和股骨近端骨密度测量,同时测定血清钙、碱性磷酸酶、甲状旁腺素、降钙素、计算甲状旁腺素/降钙素比值及24h尿钙值,比较其差异.结果:按意向处理分析,73例甲状腺功能亢进患者和73名健康对照者均完成检测,全部进入结果分析。①甲状腺功能亢进组24h尿钙、血清碱清性磷酸酶高于正常对照组[(6.56±2.48)mmol,(3296.20±664.47)nkat/L;(3.14±1.42)mmol,(1938.05±335.08)nkat/L,P<0.05]。②甲状腺功能亢进症组降钙素明显低于正常对照组[(10.47±4.67),(31.26±10.57)μg/L,P<0.05];甲状旁腺素/降钙素比值甲状腺功能亢进组明显高于正常对照组[(3.55±0.79),(1.05±0.52),P<0.05]。③甲状腺功能亢进症组患者L2～4骨密度测量值明显低于正常对照组[(0.80±0.07),(0.81±0.11),(0.82±0.09)g/cm2;(0.91±0.1),(0.90±0.09),(0.90±0.08)g/cm2;P<0.05]。④股骨近端的骨密度测量值明显低于正常对照组[(0.71±0.08),(0.62±0.12),(0.61±0.11)g/cm2;(0.82±0.08),(0.68±0.10),(0.71±0.13)g/cm2,P<0.05]。结论:甲状腺功能亢进症患者骨吸收和骨形成在高位运行,呈现高转换型骨代谢紊乱;且骨吸收作用大于骨形成,导致骨质疏松。
AIM: To analyze the changes of bone mineral density (BMD) and bone metabolism in patients with hyperthyroidism, and compare with the patients in healthy control group. METHODS: Using dual energy X-ray absorptiometry (DEXA)from January to November 2003,73 hyperthyreosis patients in outpatient Endocrinology Clinic of Haici Hospital of Qingdao and hospitalization patients and 73 healthy control people with matching age, sex, menstruation status were tested to measure bone mineral of L2-4 vertebral body and around femur, meanwhile, detect blood serum calcium, alkaline phosphatase, parathyroid hormone, calcitonin and calculate the value of parathyroid hormone(PTH)/calcitonin (CT) and 24 hours urine calcium ,and compamed the difference. RESULTS: According to intention-to-treat analysis, 73 hyperthyreosis patients and 73 healthy control people were all finished the trial, and involved in the analysis of results. ① The value of 24 hours urine calcium and alkaline phosphatase in hyperthyreosis group was higher than that in control group [(6.56±2.48) mmol,(3 296.20±664.47) nkat/L;(3.14±1.42)mmol, (1 938.05+335.08) nkat/L,(P < 0.05)]. ② CT in hyperthyreosis group was significantly lower than that in control group [(10.47±4.67),(31.26±10.57) μg/L, (P < 0.05)]. PTH/CT in in hyperthyreosis group was significantly higher than that in control group [(3.55±0.79),(1.05±0.52), (P < 0.05)]. ③ The bone mineral of L2-4 in hyperthyreosis group was lower than that in control group [(0.80±0.07),(0.81±0.11),(0.82±0.09);(0.91 ±0.1),(0.90±0.09),(0.90±0.08)g/cm2;(P<0.05)]. ④ The value of BMD around femur was significantly lower than that in control group [(0.71 ±0.08),(0.62±0.12),(0.61±0.11);(0.82±0.08),(0.68±0.10),(0.71 ±0.13)g/cm2,(P < 0.05)]. CONCLUSION: Bone resorption and bone formation in patients with hyperthyreosis was elevation run, and showed high-turnover type bone metabolism derangement; moreover, the effect of bone resorption is more than that of bone formation and lead to osteoporosis.
出处
《中国临床康复》
CSCD
北大核心
2005年第23期175-177,共3页
Chinese Journal of Clinical Rehabilitation
