2Sweet M J, Huume DA. Endotoxin signal transduction in macrophages. J Leukocyte Biol, 1996,60( 1 ):8
3Chesney J, Metz C, Stavitsky AB, et al. Regulated production of type l collagen and inflammatory cytokines by peripheral blood fibrocytes. J Immunol, 1998,160 (5): 419
5Btlding DL Textbook of Parasitology 3rdEd Philadelephia：WB-S-aunderolo，1965，98．Socranskyss，Haffajee AD，Goodson JM et al New Concepts of de-structive Rrriodontal diseage J cliu Periodontol，1984，11：21.
1Shapira L,Frolov I,Halabi A,et al.Experimental stress suppresses recruitment of macrophages but enhanced their P.gingivalis LPS-stimulated secretion of nitric oxide.J Periodontol,2000,71(3):476
2Hukkanen M,Hughes FJ,Buttery LD,et al.Cytokine-stimulated expression of inducible nitric oxide synthase by mouse,rat,and human osteoblast-like cells and its functional role in osteoblast metabolic activity.Endocrinology,1995,136(12):5445
3Batista AC,Silva TA,Chun JH,et al.Nitric oxide synthesis and severity of human periodontal disease.Oral Dis,2002,8(5):254
4Leitao RF,Ribeiro RA,Chaves HV,et al.Nitric oxide synthase inhibition prevents alveolar bone resorption in experimental periodontitis in rats.J Periodontol,2005,76(6):956
5Lohinai Z,Benedek P,Feher E,et al.Protective effects of mercaptoethylguanidine,a selective inhibitor of inducible nitric oxide synthase,in ligature-induced periodontitis in the rat.Br J Pharmacol,1998,123(3):353
6Daghigh F,Borghaei RC,Thornton RD,et al.Human gingival fibroblasts produce nitric oxide in response to proinflammatory cytokines.J Periodontol,2002,73(4):392
7Di Paola R,Marzocco S,Mazzon E,et al.Effect of aminoguanidine in ligature-induced periodontitis in rats.J Dent Res,2004,83(4):343
8Kendall HK,Marshall RI,Bartold PM.Nitric oxide and tissue destruction.Oral Dis,2001,7(1):2
10Rosen G,Sela MN,Naor R,et al.Activation of murine macrophages by lipoprotein and lipooligosaccharide of Treponema denticola.Infect Immun,1999,67(3):1180
