摘要
目的分析脑恶性淋巴瘤的临床特点及原发性和继发性脑恶性淋巴瘤的差别、治疗和预后情况。方法1990年4月30日～2001年4月30日我科收治15例脑恶性淋巴瘤患者中,原发性6例,继发性9例,中位年龄55.7岁。原发组均为非霍奇金淋巴瘤,继发组1例霍奇金淋巴瘤,其余为非霍奇金淋巴瘤,全部患者均接受脑放疗。结果近期疗效尚好,原发组6例中CR4例,PR2例;继发组9例中CR4例,PR5例。远期疗效不佳,原发组首次治疗后的生存时间为8～47个月,平均生存期为16个月,1年生存率62.5%;继发组生存时间6～8个月,平均生存期11个月,1年生存率35.7%。结论脑恶性淋巴瘤预后不良,继发性比原发性预后更差,放射剂量提高并不能提高肿瘤控制率,综合治疗可能有望改善疗效。
OBJECTIVE: To analyse the clinical features, treatment result and prognosis of primary and secondary cerebral malignant lymphoma.METHODS: Six cases of primary and 9 cases of secondary cerebral malignant lymphoma were admitted from April 1990 to April 2001, with a median age of 55.7 years old. There was one case of Hodgkin's lymphoma in secondary cases, the others were Non-Hodgkin's lymphoma all the patients received cerebral radiotherapy. RESULTS: The effect was good in the near future. There were 4 CR and 2 PR in primary cases and 4 CR and 5 CR in secondary cases, but the prognosis was poor. The 1 year survival rates were 62.5% for the primary cases and 35.7% for the secondary cases. CONCLUSIONS: The prognosis of cerebral malignant lymphoma is poor and that of secondary cases even worse. Escalation of radiation dose couldn’t get better control. The combined treatment may improve the patient's survival.
出处
《肿瘤防治杂志》
2005年第14期1090-1092,共3页
China Journal of Cancer Prevention and Treatment
关键词
脑肿瘤/治疗
淋巴瘤/治疗
综合疗法
回顾性研究
预后
brain neoplasms/therapy
lymphoma/therapy
combined modality therapy
retrospective studies
prognosis
