摘要
作者研究了７８例骨肿瘤细胞核仁组成区嗜银蛋白（ＡｇＮＯＲ）的表达，对其中３６例比较了ＡｇＮＯＲ计数和ＤＮＡ含量流式细胞分析的结果，对４６例骨肉瘤探讨了ＡｇＮＯＲ数的临床意义。结果表明：（１）良性、低度恶性和高度恶性骨肿瘤ＡｇＮＯＲ数分别为１．７１±０．３６；３．１５±０．６２和３．９９±１．００，其差异有统计学意义；（２）ＡｇＮＯＲ数与ＤＮＡ含量分析提供的ＤＮＡ指数、Ｓ期细胞百分数、Ｇ＿２／Ｍ期细胞百分数及增殖指数的相关关系分别为：０．３０４５、０．５９３７、０．３５０６和０．６２６０，其对应的Ｐ值为：＞０．０５、＜０．０１、＜０．０５和＜０．０１；（３）ＡｇＮＯＲ数一定程度上反映了骨肉瘤的某些临床特点：ＡｇＮＯＲ数高者倾向于有较大的肿瘤体积、较晚的外科分期和较差的预后。
AbstractThe expression of silver-stained nucleolar orga-nizer region proteins (AgNORs) in 78 bone tumorswas studied. The results of DNA flow cytometry andAgNOR counts in 36 tumors were compared and theclinical significance of AgNOR counts in 46 cases ofosteosarcoma was investigated. We found:(1)TheAgNOR counts of benign,low-grade and high-grade malignant bone tumors were 1.71±0.36,3.15±0. 62 and 3.99±1.00, respectively. The differencesamong them had statistical signiflcance.(2) The rela-tive coefficient of AgNOR count and DNA index,s-phase cell percentage,G_2/M cell percentage,prOlifer-ating index were 0.3045,0.5937,0.3506 and 0.6260,P>0.05,P<0.01,P<0.05,and P<0.01 corre-spondingly.(3)AsNOR counts represented someclinical characteristics of osteosarcoma.There was atendency that the higher the AgNOR counts, the big-ger tumor volume, and the later surgical stage andpoorer the prognosis.
出处
《中华骨科杂志》
CAS
CSCD
北大核心
1995年第12期841-844,共4页
Chinese Journal of Orthopaedics
