摘要
目的:研究TopoⅡ在膀胱癌中表达的意义。方法:应用免疫组化SP法,检测72例膀胱癌组织中TopoⅡ的表达。结果:TopoⅡ在膀胱癌中的阳性表达率为45·83%(33/72)。TopoⅡ的表达与膀胱癌的分级呈正相关(P<0·05),与膀胱癌的分期无显著性差异(P>0·05),但随分期的递增呈升高趋势。结论:TopoⅡ的表达与癌组织的分级和分期有关。检测TopoⅡ表达情况可为抗癌药物的筛选提供依据。
Objective: to study the expression of TopoⅡ in bladder carcinoma . Methods: immunohistochemical metho d was performed for TopoⅡ on 72 cases with bladder carcinoma. Results: the total positive rate of TopoⅡ was 45.83%(33/72).The expression of T opoⅡwas associated with grading of bladder transitional cell carcinoma( P<0.05),there is insignificant differece between two clinnical stage of bladder transitional cell carcinoma, but the positive rate of TopoⅡ was increa sed with the increase of clinical stage. Conlusion: the expressi on of TopoⅡ was associated with grading and clinical stage of bladder transitio nal cell carcinoma. To examine the expression of TopoⅡcan be helpful for choosi ng proper anti-carcinoma drugs for patients with bladder carcinoma.
出处
《河北北方学院学报（医学版）》
2005年第3期14-15,共2页
Journal of Hebei North University:Medical Edition
