摘要
目的:观察动物对颈舒颗粒的急性和慢性的毒性反应。方法:灌胃给药测定小鼠最大给药量,观察7d内动物的死亡情况;大鼠分对照组,颈舒颗粒高、中、低剂量组(24,12,6g.kg-1/d),连续灌胃12周。结果:颈舒颗粒的小鼠的最大给药量为120g.kg-1/d,相当于临床成人用量的100倍以上。大鼠长期灌服颈舒颗粒,动物一般状况、血液和血液生化指标、脏器系数、病理解剖观察均未发现明显异常,与对照组相比均无明显差异。结论:颈舒颗粒未见有明显毒性反应,表明本品安全性较高。
To observe the acute and long-term toxicity of Jingshu Granule on mice and rats respectively. Method: The maximal dose was tested by gastric perfusion, observing the death circumstance of the animal in 7 days; Rats was divided control group, three groups of high, moderate and low dosage of Jingshu Granule (24,12,6 gkg^(-1)/d) with repeated gastric perfusion for 12 weeks. Result: The maximal dose is 120 gkg^(-1)/d, more than 100 times of the dosage used in clinic for an adult. Rats were perfused drug long term, the indexes of general condition, blood routine testes , blood chemical analysis, organ coefficient of rats, pathological anatomic examination were not found obvious abnormality, there was no significant difference between the test groups and the control in all tested parameters . Conclusion: Jingshu Granules did not see the obvious toxicity responds toxicity,we conclude that this drug has better safty.
出处
《安徽中医学院学报》
CAS
2005年第4期40-42,共3页
Journal of Anhui Traditional Chinese Medical College
关键词
颈舒颗粒
急性毒性实验
慢性毒性实验
<Keyword>Jingshu Granule
Acute toxicity
Long-term toxicity
