摘要
目的观察恩丹西酮预防恶性肿瘤化疗引起的恶心、呕吐,食欲不振等反应的效果。方法85例患者。A组50人,使用化疗药物前未肌注恩丹西酮;B组35人,化疗药物使用前后肌注恩丹西酮8mg,每日两次或更多。结果A组与B组恶心的反应率分别为94%,74%,两组间差异有显著性。A组与B组呕吐的反应率分别为70%、45.72%,两组间差异极显著。A组与B组食欲不振的反应率分别为96%、62.86%,两组间差异极显著。结论恩丹西酮可减少化疗引起的消化道反应,对进一步化疗的顺利进行有重要意义。
Objective To observe the effects of ondansetron on prevention and treatment of the nausea, vomiting and poor appetite that may occur after anticancer medicines (chemotherapy). Methods Total 85 patients were divided into group A in which 50 patients without injection of ondansetron before chemotherapy and group B in which 35 patients with injection of ondansetron by dosing 8mg bid or more daily before and after chemotherapy. Results Occurring rate of the nausea was 94% in group A and 74% in group B with significant difference. Occurring rate of the vomiting was 70% in group A and 46% in group B with high significant difference. Occurring rate of the poor appetite was 96% in group A and 63% in group B with high significant difference. Conclusion Ondansetron may reduce the side effects of chemotherapy on the digesting tract, which should be important to strengthen surgery result and complete chemotherapy successfully .
出处
《现代肿瘤医学》
CAS
2005年第4期496-497,共2页
Journal of Modern Oncology
