摘要
为了制订间苯二酚卫生标准对其毒性进行了一系列的研究。间苯二酚大鼠经口ＬＤ５ｏ７４５．３ｍｇ／ｋｇ，小鼠经口ＬＤ５０２８６．９ｍｙ／ｋｇ；亚慢性阈浓度为（３７．１２±２．３６）ｍｇ／ｍ３；蓄积系数Ｋ大于５．８２，属弱蓄积级（Ｋ１记分２）；动物间敏感性差异小于或等于３（Ｋ２记分２）；无肯定致癌、致畸和致突变作用。最高容许浓度的安全系数可定为４．最高容许浓度值１０／ｍｇ３。比美国ＡＣＧＩＨ和英国ＨＳＥ标准有更好的保护水平；
Resorcinol is used commonly in industries. In order to collect necessary data for establishing
its maximum allowable concen-tratio,a series of studies were carried out. The results showed
that the LD50 of resorcinol in rats and mice were 745.3mg/kg and286.9mg/kg respectively,the
subchronic inhalation threshold concentration was 37.12±2.36 mg/m3 .The accunlulated
coeffi-cient K appeared to be more than 5. 28. being rated as weak accumulation(K=2). The
degree of different sesnsitivity among vari-ous animals was equal to or less than 3. Neither
evidence of mutagenicity nor that of teratogenicity has been confirmed. Therefore,safety
coefficient was suggested to be 4. The maximum allowable concentration for resorcinol was
established as l0 mg/m3. Sucha hygienic standard seems to have a better protective level than
the TLV suggested by ACGIH in U.S.A.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
1995年第3期154-156,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
基金
中国预防医学科学院资助
关键词
间苯二酚
毒性
车间卫生标准
Resorcinol Toxicity Maxinum allowable
concentration in workplace
