摘要
３０例择期手术者于芬太尼、普鲁卡因静吸复合麻醉后，静注多沙普仑逆转呼吸抑制／催醒时 效。观察用药前、用药后１、２、４、６、８、１０ｍｉｎ和拔管后潮气量（ＶＴ）、呼吸频率（Ｒ）、血压、心率及脉搏氧饱和 度（ＳＰＯ２）变化情况。结果表明，多沙普仑１．０ｍｇ·ｋｇ－１有明显地兴奋呼吸作用，静注后１～２ｍｉｎ内ＶＴ、Ｒ 即可达高峰，分别由用药前２２３．６７±１６３．４４ｍｌ、１３．０±６．８５ｂｐｍ增至５１５．６７±２４７．３７ｍｌ和２０．４７± ６．３０ｂｍｍ（Ｐ＜０．０１）。其后虽略有下降，但仍可恒定维持高水平（ＶＴ≥１０ｍｌ·ｋｇ－１、Ｒ≥１６ｂｐｍ）。拔管后 ＶＴ、Ｒ分别为４５９．６７±１５４．０６ｍｌ和１９．２±４．１６１ｂｐｍ，与用药前比较差异十分显著（Ｐ＜０．０１）。药物总有 效率１００％。催醒时间４．０±３．０１ｍｉｎ，催醒率８０％。药物对ＳＢＰ、ＤＢＰ、ＨＲ无明影响（Ｐ＞０．０５）。ＳｐＯ２呈下 降趋势，可能与停纯氧吸入有关。所有患者均于用药后１０～２０ｍｉｎ内拔除气管导管，未见有呼吸再抑制 现象。
The effects of Intravenous doxapram on stimulating respiration and awakening and hemodynamics were studied in thirty patients at foe end of the intravenous fcntanyl and procaine combined with inhaled enflurane general anesthesia. The results showed that within one or two minutes after intravenous doxapram 1. 0mg/kg,tidal volume (VT) and respiratory frequency (RF) increased significantly from 223. 67163. 44 ml and 13. of 6. 85 bpm to 515. 67247. 37 ml and 20. 47 6. 30 bpm respectively (P<O. 01 ). in spite of slight reductions following,VT and RF were kept at high level (VT10ml/kg and RF16 bpm),after extubation became 459. 67f 54. 06 ml and 19. 2 4. 16 ppm with dramatic elevations compared with the levels before its administration (P< 0. 05 ). Within eight minutes (4. 03 3. 01 min) after doxapram,twenty-four patients were awaked. with awakening rate being 80% There weren't significant varations in blood pressure, heart rate and SpO2 following intravenous doxapram. There weren't the postoperative incidences of the recurrent respiratory depression. It's concluded that doxapram may be applied effectively and safely to stimulating respiration and awakening after the introvenous fentanyl and procaine combined with inhaled agents general anesthes la.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1995年第8期367-369,共3页
Chinese Journal of Anesthesiology
关键词
多沙普仑
芬太尼
普鲁卡因
呼吸抑制
全麻
Doxapram Combination of intravenous and inhaled anesthesia Respiratory depression
