摘要
以形态学、芽管试验、血清学方法对８８株临床致病念珠菌株进行了分类鉴定，对比随机扩增多态性ＤＮＡ－聚合酶链反应的带型进行分析。分析结果表明，白念珠菌仍然是最常见的致病念珠菌，但存在着一种菌种变迁趋势，热带念珠菌和近平滑念珠菌的分离率合计约与白念珠菌的分离率相等，呈明显上升趋势。这种趋势除对治疗具有重要的指导作用外，还提示我们应发展更好的抗真菌药物。文中还对各种鉴定的方法进行了评估。
Eighty-eight Candida strains isolated from clinical specimens were classified by morphological test, germ tube test, and serotyping, and patterns obtained were further analysed by randomly amplified polymorphic DNA markers-polymerase chain reaction (RAPD-PCR). The results showed that Candida albicans was still the most common among Candida species. However, there is a 'shift' trend because non-C. albicans species infection, especially C. tropicalis and C. parapsilosis infections markedly increased, and the infections caused by these two species almost equal to C. albicans infection. This 'shift' trend will be important not only for guiding the clinical treatment, but also for the development of new antifungal agents. In this paper, the methods used for identification were also evaluated.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
1995年第6期375-378,共4页
Chinese Journal of Dermatology
基金
卫生部基金资助项目
