摘要
对１８例常规透析患者进行了无醋酸盐透析（ＡＦＨＤ）治疗研究，并以同期１８例醋酸盐透析（ＡＨＤ）患者作对照。结果表明，ＡＦＨＤ对中小分子物质以及β２－Ｍ清除与ＡＨＤ比较无差异（Ｐ＞０．０５）。应用ＫＴ／Ｖ，ＰＣＲ，ＴＡＣｕｒｅａ评价透析效果，证明透析充分，ＡＨＤ后ＴＮＦ及ＩＬ－６基因表达显著高于ＡＦＨＤ，而ＴＧＦ－β组间无差异。ＡＨＤ后升高，而ＡＦＨＤ后降低。两组患者透析后ＳＯＤ均降低。ＡＦＨＤ对磷的清除、以及纠正代谢性酸中毒均优于ＡＨＤ，无低氧血症，副作用少。
n this paper, we prospectively investigated thepossibilrty of using acetatefree
dialysate in bicarbonate hernodialysis instead of routine hernodialysis. Pa-tients were
randornly divided into 2 groups. 18 pateintswere acetate hemodialysis (AHD) and 18 patients
wereacetatefree dialysate hemodialysis (AFHD). The results suggested: in AFHD, all the
patients felt welland no one felt weak; There was no significant difference in creatinine , MMs
and β2-M between AHD andAFHD and no significant difference in KTIV , PCR andTACurea
between AHD and AFHD either. The plasmaIL 6 increased in 7 patients with AHD and 3 inAFHD.
The plasma IL-6 had no change in 5 patientswith AHD and 3 in AFHD. TNF was significantly
increased after the end of dialysis session in AHD (P<0. 05) but had no change in AFHD. There
was no sig-nificant difference in TGF 0 between AHD andAFHD. In AHD CD.+ was significantly
increasedat the end of dialysis session (P<0. 05)and CDs+ had no change. AFHD had no
changebut CDJ was significantly decreased at the end of dialysis observed. Frorri these
results we can conclude thatacetate dialysate can stimulate the synthesis of theTNF, IL- 6 and
T help cell may be very close to somecytokines. We highly recornmend using AFHD to takethe
place of AHD in patients with chronic renalfailure.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1995年第1期16-19,共4页
Chinese Journal of Nephrology
