摘要
用氢清除法和电子自旋共振等方法测定了５／６肾切除大鼠术３０～１２０天残肾的有关指标，发现饲以普通饲料的Ⅱ组大鼠残肾组织皿流量和氧自由基含量显著增加，抗氧化能力显著下降，肾功能进行性恶化，残肾炎性细胞浸润和纤维化显著；饲以大剂量维生素Ｅ的Ⅲ组大鼠，残肾血流量也显著增加，但氧自由基含量无显著增加，抗氧化能力无降低，肾功能和形态损害显著轻于Ⅱ组，动物死亡率显著低于Ⅱ组。提示残肾高灌注引起的氧自由基增高在残肾的进行性毁损中起有重要作用。
ome
biochernical,physical and histological obser-vations of remnant kidney in 5/6 nephrectomy
chronicrenal failure rats were performed when 30～120 daysafter Operation using hydrogen
gas clearance tech-nique, electronspinresonance spectroscopy, and soon.In group Ⅱ feeded
with common feed,the bloodflow and oxygen free radical content of remnant kidneytissue
increased markedly compared with the sham-operation control group, accomplied by decreased
renalanti oxidative ability, renal function insufficiency, andleucocyte infiltration and fibrosis in
rernnant kidney. Ingroup Ⅲ feeded with feed contained high vitarnin E, theblood flow of
remnant kidney tissue increased as muchas group Ⅱ, but the renal free radical content
showednormal, with normal renal anti-oxidative ability , andless functional and histological
impairment of remnantkidney than group Ⅱ. The mortality of group Ⅲ waslower than group Ⅱ.
These data suggested that en-hancement of renal oxygen free radicals caused by
hy-perperfusion played an irnportant role in the impair-ment of remnant kidney.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1995年第3期144-148,共5页
Chinese Journal of Nephrology
基金
全军青年基金
关键词
肾功能衰竭
残肾
血流量
氧自由基
Chronic renal failure Renal bloodflow Oxygen free radicals Electron-spin-res-Onance
