摘要
研究了无醋酸盐血液透析（ＡＦＨＤ）和碳酸氢盐血液透析（ＢＨＤ）对一些细胞因子和生化参数的影响。８例ＡＦＨＤ和８例ＢＨＤ患者在实验第１周采用原透析方式，第２周互相交换，所有患者ＡＦＨＤ和ＢＨＤ前后的结果进行比较显示：ＡＦＨＤ和ＢＨＤ均能有效地清除尿毒症小分子物质，纠正低钙血症和高磷血症，但ＡＦＨＤ后血磷降低更明显；ＡＦＨＤ和ＢＨＤ前后外周血肿瘤坏死因子（ＴＮＦα）和可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）浓度均无变化，ＢＨＤ后白细胞介素－１（ＩＬ－１）活性显著增加，而ＡＦＨＤ后ＩＬ－１活性也无变化。结果表明ＡＦＨＤ比ＢＨＤ清除血磷更充分，对影响细胞因子生成的作用更小。
patients who were treated with either bicarbonate or acetate-free hemodialysis thrice aweek, were involved in this two week period study.8 patients were dialysed with bicarbonate dialysate within the first week,and changed to acetate-free hemodialysis(MHD)the next week,others were treated with AFHD followed bicarbonate hemodialysis(BHD).Blood was sampled at the beginning and the endof the first dialysis of the week on each dialvsate. The result indicated that the serum phospho-rous was significantly decreased after both BHD and AFHD,but it was lower after AFHD versus BHD.TNFα and sIL-2R did not changed during BHD and AFHD,Serum IL-1 activity increased markedly dur-ing BHD but unchanged during AFHD. The more effective clearance of phosphorus during AFHD may play a role in the prevention of Osteopathy and cytokines are less affected by AMHD.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1995年第6期335-339,共5页
Chinese Journal of Nephrology
