摘要
作者利用抗原－抗体的免疫中和反应原理，观察了大鼠脊髓中度损伤后，鞘内分别注射强啡肽Ａ抗血清、β－内啡肽抗血清和亮脑啡肽抗血清对大鼠脊髓继发性损伤的对抗作用。结果表明，强啡肽Ａ抗血清对大鼠脊髓继发性损伤的保护作用最为明显。而且，脊髓损伤后即刻，伤后４小时，以及伤后１周或２周，应用强啡肽Ａ抗血清的作用效果均不如伤后２４小时给予者。提示脊髓创伤后脊髓组织中强啡肽Ａ的升高，在早期可能有其积极的一面，但在过量积聚之后，对脊髓继发性损伤的不利作用越来越明显。
AbstractThe antagonistic effects of antisera against dynor-phin A,β-endorphin, and leu-enkephailin administeredIntrathecally on secondary SCI were observed and com-pared after moderate SCI using principle of antigen-an-tibody neurtralization reaction, The protective effect ofantiserum against dynorphin A was most prominent onsecondary SCI and the effect was more prominent whenadministered at 24 hours following SCI than whenadministered at 0 hour four hours, one week or twoweeks following SCI. That suggests increase of dynor-phin A level in spinal cord tissue may play an activerole in the early stage, but its harmful effect on sec-ondary SCI will be more and more prominent after ac-cumulation of excessive dynorphin A.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1995年第12期723-726,共4页
Chinese Journal of Surgery
基金
国家自然科学基金
