摘要
应用脂质体包埋冬虫夏草多糖（ＣＰ）口服３个月治疗肝炎后肝硬化（ＰＨＣ）２８例，在治疗前、后第２、３个月分别检测外周血Ｔ细胞免疫功能指标和肝功能。结果：①ＰＨＣ患者外周血ＣＤ４，细胞比例、ＣＤ４／ＣＤ８比值、自然杀伤细胞（ＮＫ）活性及经ＰＨＡ－Ｐ诱导的外周血淋巴细胞（ＰＢＬ）、膜白细胞介素２受体（ＩＬＭ－２Ｒ）的表达，白细胞介素２（ＩＬ－２）和γ－干扰素（ＩＦＮ－γ）。的生成均显著低于正常对照（Ｐ值分别＜０．００１，＜０．０１，＜０．００１，＜０．０１，＜０．００１和＜０．００１），而血清ｓＩＬ－２Ｒ水平则显著升高（Ｐ＜０．００１）。②服用ＣＰ脂质体（ＣＰｌ）３个月后，ＰＨＣ患者的外周血ＣＤ４／ＣＤ８比值、ＮＫ活性及经ＰＨＡ－Ｐ诱导的ＰＢＬＭＩＬ－２Ｒ表达，ＩＬ－２和ＩＦＮ－γ生成均较治疗前显著升高（Ｐ值分别＜０．０５，＜０．０１，＜０．０１，＜０．０５和＜０．０５），而血清ｓＩＬ－２Ｒ水平则显著下降（Ｐ＜０．０５）；同时其肝功能亦有明显改善。因而证实了ＣＰＬ对Ｔ细胞免疫的调节作用及其对ＰＨＣ的疗效。
ordyceps
polysaccharide(CP)is the main active ingredient of Cordyceps Sinensis whichis capable of
enhancing phagocytosis and modul ating cellular immune funtions. The aim ofthis study is to
investigate the effects of Cp-liposome(CPL) on T cell immunity in patientswith post-hepatitic
cirrhosis. The resuIts showed:(1) The proportion of CD4 + in PBL,the CD4+/CD8+:ratio,
expression of MIL-2R and production of IL-2 and IFN-γ, NK activity in post-hebatiticcirrhotic
patients were markedly lower than those in normal controls(P< 0.001,<0.01,<0.01,<0.001,<0.00l
and <0.001, respectively),whereas the serum levels of slL-2R Wassignificantly higher than that
in normal controls (P< 0.001).(2) After treatment with oralCPL for 3 months, CD4+ /CD8 + ratio
and NK activity of PBL, production of IL-2 and INF-γand expression of MIL-2R induced by
PHA-P in patients with PHC was significantly higherthan those prior to treatment (P<0.05, <0.01,
<0.05, <0.05, <0.01, respectively), and theserum level of sIL-2R was significantly lower
(P<0.05).Moreover,liver functions in patientswith PHC was also significantly improved.These
preliminary resuIts indicate that CP embedded in liposome which carries the druginto the cells
and acts also as an immunoanvant, would potentiate the therapeutic effects ofthe former.Such a
new form of drug preparation is worthy of further clinical trial for PHC.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1995年第5期265-268,共4页
Chinese Journal of Digestion
关键词
肝硬变
T细胞
免疫
干扰素
冬虫夏草
糖脂质体
T cell
immunity
Interleukin 2
Interferon-gamma
embrane/Solubleinterleukin 2 recptor
Cordyceps
polysaccharide-liposome.
