摘要
总结１６１例成人急性病毒性心肌炎用聚合酶链式反应法检测血中柯萨奇病毒Ｂ核酸片段的结果，并与非心肌炎组９８例对比研究。结果：阳性检出率心肌炎组５７．８％，对照组４．１％（Ｐ＜０．０１），诊断特异性９５．９％。男、女性病人间阳性率差异无显著性。由于该法能快速、早期、准确检出病毒感染，比检测相应抗体阳性率高而早，特异性高，因此，可作为急性病毒性心肌炎患者近期病毒感染的辅助诊断方法。
Abstract Polymerase chain reaction (PCR) technique was used to detect blood Coxsakie B virus DNA fragments (CVB) in 161 cases of adult acute viral myocarditis and 98 cases of controls. In the myocarditis group positive rate of CVB was 57. 8 %. but in the control group only 4. 1 % (P< 0. 01 ). No difference in the positive rate was found between males and females. The diagnostic specificity of viral infection was 95. 9 % . Viral infection could be earlier, more rapidly, and correctly diagnosed by he PCR method which had higher specificity than serum antibody titer for CVB. As blood CVB was lowly or moderately associated with viral myocarditis,the detection of blood CVB might assist rapid diagnosis of acute viral myocarditis.
出处
《中华心血管病杂志》
CSCD
北大核心
1995年第2期122-123,共2页
Chinese Journal of Cardiology
