摘要
随访２３例因重症肌无力行胸腺切除术的病人。运用灵敏度高、特异性强的ＢＡＳ—ＥＬＩＳＡ法检测手术前、后血清乙酰胆碱受体抗体（ＡｃｈＲ抗体）水平，所得结果均进行统计学分析。２３例病人胸腺切除后，１８例临床症状改善，有效率７８％。术后１４例（６１％）病人血清ＡｃｈＲ抗体水平下降，统计结果表明，手术前后血清ＡｃｈＲ抗体水平差异有显著性（Ｐ＜０．０５），但与症状改善无关（Ｐ＞０．０５）。手术前后血清ＡｃｈＲ抗体水平不影响疗效（Ｐ＞０．０５）。
A series of 23 patients with myasthenia gravis treated by thymectomy were studied and followed up.Before and after operation,the patients serum acetylcholine receptor antibody(AchR antibody)level was also detected by ABC-ELISA, which is considered sensitive and specific.All results were evaluated statistically.18 cases improved clinically after thymectomy.By detecting the serum AchR antibody level,showing that it was declined after thymectomy in 14 cases.Statistical analysis indicated that marked difference between the preoperative and postoperative serum levels of AchR exited in all patients (paired t test;P<0.05),but there was no correlation between serum AchR antibody level and clinical improvement (P>0.05 ).
出处
《中华胸心血管外科杂志》
CSCD
北大核心
1995年第1期12-13,共2页
Chinese Journal of Thoracic and Cardiovascular Surgery
关键词
重症肌无力
胸腺切除术
乙酰胆碱受体抗体
Myasthenia Gravis
Thymectomyt
Serumacetylcholine receptor antibody
