摘要
为探讨住院病人带真菌情况及其临床意义，作者对住院３天以上的１１０９例病人的腔孔（眼内眦、鼻前庭、外耳道）、皮肤（指缝、肘窝、腋窝、乳头）和粘膜（咽、阴道、冠状沟和肛管）共１１个部位取材培养真菌，并检查２０１名健康人作为对照组。结果：总带菌率：病人组为８８．７３％，对照组为７６．６２％，差异有显著意义（χ２＝２１．６１）。在病人组中，白血病、肿瘤、结缔组织病、重症感染和内分泌性疾病者的带菌率明显高于其他病人（χ２＝４．３０～９．８７）。病人组和对照组的带菌率均以腔孔部最高，分别为８０．７０％和７１．６４％；皮肤最低，分别为２０．０２％和１３．４３％；粘膜带菌率分别为５０．７７％和３２．３４％。差异均有显著意义。带菌总株数：病人组１８８４株（念珠菌５６１株，占２９．７８％；曲霉菌４５８株，占２４．３１％），平均为１．９２株／例；对照组２３４株（青霉菌１０６株，占４５．３０％；酵母菌６１株，占２６．０７％），平均为１．５２株／例。病人组中人院３～１０天和２０天以上者带菌率较住院１０～２０天者高（χ２＝５．６３３～９７．０９）。用抗生素和皮质激素以前和用药２０天以上者带菌率较用药１～２０天者高（χ２＝５．５６～１１?
he sarnples for fungi culture were
collected from11 body parts of 1109 patients who had been admittedto hospitals in Wuhan for
more than 3 days. The bodyparts included the cavities and foramina tinner can-thus, nasal
vestibule, external auditory canal) , skin( finger raphe, cubital fossa , axillary fossa , nipple)
,and mucosa (pharynx, vagina, coronary sulcus andanal canal). 201 healthy subjects were also
examinedand served as controls. It was found that the total fun-gusbearing rate in hospitalized
patients was 88. 73%(984/1109), while the rate in healthy suhJect was76. 62% (154/201) (X2 =
21. 61). Among the hospi-talized patients, the fungus-bearing rate in patientswith leukemia,
tumors, connective tissue diseases orsevere infectious diseases was significantly higher
thanother patients (X2 = 4. 30～9. 87). In the hospitalizedpatients, the body parts with highest
fungus-bearingrates were cavities and foramina , 80. 70 % ( 895/1109)for patients and 71.
64%(144/201 ) for healthy sub-jects respectively. The skin had lowest fungus-bearingrate. 20.
02% (222/1109) and 13. 43% (26/201),and the mucosa had a rate of 50. 77% (563/1109)
forpatients and 32. 34% (65/201) respectively. The fungiin the hospitalized patients included
1884 strains (mean= 1. 92 strains per case) in which the Candida account-ed for 29. 78%
(561/1884) and Aspergilla 24. 31%( 458/1884) and those identified in healthy subjectscovered
234 strains (mean = 1. 52 strains per person) inwhich Peniczllia accounted for 45. 30% (106/234)
andSarcharomycetes 26. 07% (61/234 ). The patients whohad been hospitalized for 3～10 days
and over 20 dayshad higher fungusbearing rate as compared with thosewho had been
hospitalized for 10 to 20 days (X2=5. 633 ～ 97. 09 ). The patients before the administra-tion of
antibiotics and adrenocortical steroid and thosewho had been given these medicines for over 20
dayshad a higher fungusbearing rate than those who hadbeen on these medicines for 1～20
days.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1995年第9期552-556,共5页
National Medical Journal of China
基金
国家自然科学基金
