摘要
观察了维甲酸对体外培养成纤维细胞DNA合成的影响,结果证明维甲酸对其合成有不同程度的抑制作用,呈剂量效应关系,并探讨了维甲酸治疗瘢痕的可能作用机理。
The effect of retinoic acid on DNA synthesis of fibroblast was studied in vitro culture.The results demonstrated that retinoic acid significantly(P<0.01)inhi- bited the DNA synthesis of fibroblast in vitro culture and a dose-dependent relationship between DNA synthesis and retinoie acid concentration was observed.The possible mechanism of retinoic acid used for the treatment of sear was discussed.
基金
卫生部科研基金
关键词
瘢痕
成纤维细胞
维甲酸
细胞培养
药理
Retinoic acid
Fibroblast
Scar
~3H-TdR incorporation
Cell culture
