摘要
作者用随机分组研究，观察了４３例无远处转移鼻咽癌患者经放射合并西咪替丁（ＣＭＤ）治疗和单纯放射治疗后的细胞免疫功能变化。结果表明，放射合并ＣＭＤ治疗后，外周血Ｔ淋巴细胞ＣＤ＿４增多，ＣＤ＿８减少，ＣＤ＿４／ＣＤ＿８比率升高，ＮＫ活性和ＩＬ－２产生水平都增高。单纯放疗后，ＮＫ活性和ＣＤ＿４细胞增加，其他无显著变化。放射合并ＣＭＤ治疗组的ＣＤ＿４／ＣＤ＿８比率、ＩＬ－２产生水平和ＮＫ活性的变化幅度都高于单纯放疗组。提示ＣＭＤ能调节鼻咽癌患者的细胞免疫功能，是一种有效的免疫调节剂。
Abstract
Cimetidine(CMD),an H2 receptor antagonist, was used in combination
with radiation forthe treatment of patirnts with nasopharyngeal
cancer(NPC).In patients treated with radiothera-py alone,there was an
increase in the number of CD_4￣+ T cells and in NK cell activity. In
pa-tients received combined treatment of radiation and CMD,in
addition,there was a decrease inCD_8￣+ T cells with an increase in
CD_4/CD_8 ratio and an increase in IL-2 production,The NK
cellactivity was also stronger in the latter group.The results
suggest that CMD helps restore cell-mediated immunity in NPC patients
radiation treated.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1995年第3期223-225,共3页
Chinese Journal of Oncology
