摘要
本文对２４例氟中毒患者的淋巴细胞的姊妹染色单体互换（ＳＣＥ）频率和微核率进行观察，结果表明氟中毒患者的ＳＣＥ频率明显高于正常对照组（ｔ检验，Ｐ＜０．０１），说明氟中毒可引起ＤＮＡ损伤致使ＳＣＥ频率增加．氟中毒患者的淋巴细胞微核率与正常对照组比较（Ｘ２）检验，Ｐ＜０．０１）患者组明显高于对照组，这说明氟中毒也可引起染色体断裂导致染色体畸变．
Sister chromatid exchange(SCE) and micronucleus frequencies of lymphocyte wereexamined in 24 cases of fluorosis.The results show that SCE and micronucleus frequencies of thesick group are obviously higher than health group. t-test show P<0.001 in SCE,and x2-test showP<0.01 in micronucleus. The results suggest that fluorosis may lead to increase in SCE,chromo-some breakage and aberration.
出处
《蚌埠医学院学报》
CAS
1995年第6期367-369,共3页
Journal of Bengbu Medical College
关键词
氟中毒
姊妹
染色单体互换
微核率
染色体畸变
fluorosis
sister chromatid exchange(SCE)
lymphocyte
micronucleus
chromoso- mal aberration
