摘要
从细胞形态、流式细胞术、－ＤＮＡ／蛋白质含量及ＤＮＡ电泳等实验证明，在相当于临床治疗剂量范围内，乐铂对ＨＬ－６０细胞的杀伤作用主要为诱发白血病细胞的程序化死亡。
poptosis
plays an important role in tumorigenesis and cancer treatrment.In
this study, we observed the ef-fects of Lobaplatin(a new derivative
of platin family, produced by ASTA, Germany)on HL-60 cells. From
viablecell count, morphology changes, FCM-DNA/Protein dual parameter
analysis and DNA electrophoresis, apoptosiseffect on HL-60 cells
induced by Lobaplatin was dose-and time-dependent. Cells exposed to
20 μg/ml of Lobaplatinfor 24 hours showed a maximum effect. The
dosage was equivalent to that in vivo treatment.
出处
《北京医科大学学报》
CSCD
1995年第3期173-175,共3页
Journal of Peking University(Health Sciences)
关键词
细胞凋亡
乐铂
药理学
白血病
药物疗法
抗癌药
Headings
Apoptosis*
Lobaplatin*/ pharmacol
Leukemia/drug ther
Cell
survival/drug eff
