摘要
通过对13例重度妊高征患者采用快速(120mg·kg^(-1)·h^(-1))、慢速(24mg·kg^(-1)·h^(-1))静脉相继滴注硫酸镁的方法进行治疗,探讨临床药动学特征和给药方案的临床合理性.测定不同时间点的血清镁浓度,对血药-时间关系用计算机程序分别按一室、二室快慢滴注模型进行拟合,求算药动学参数.结果显示:血药浓度的时间过程符合二室模型,两种不同的速率相继滴注优点是安全、稳妥,主要动力学参数为;α为4.59h^(-1).t_(1/(2α))为0.23h,β为0.18h^(-1),t_(1/(2β))为4.53h,V_c、C_β分别为 0.22、0.571/kg,K_(10)为 0.87h^(-1).硫酸镁在重度妊高征患者中的分布容积增大,半衰期延长,消除减慢.
The clinical pharmacokinetic properties of magnesium sulfate after two consecutive intravenous infusion (120 mgo kg-1oh-1 in I h and 24mg okg-2 oh-1 in 5h)were studied in 13 severe pregnancy induced hypertension (PIH) patients. The blood samples were collected at 0, 0.5, 1 , 2,4, 6,7,9, 11 ,13, 15 h and the serum magnesium concentration was determined by spectrophotometric method. The drug concentration-time data were simulated to one and two-compartment open model respectively. The present study indicated that a biexponential equation was better fitted to. The pharmacokinetic parameters were as the following:a=4. 59h-1,t1/2a=0. 23h,B=0.18h-1,t1/2B=4.53h,Vc=0.22 1/kg,VB=0.57 1/kg,K10=0.87 h-1,K12=2.64 h-1,K21 =1.56 h-1. The distribution volume, half life and elimination of magnesium in severe pregnancy induced hypertension were reduced,lengthened,and slow respectively.
出处
《海军总医院学报》
1995年第3期143-148,共6页
Journal of Naval General Hospital of PLA
关键词
妊娠高血压
综合征
硫酸镁
药代动力学
静脉滴注
:Pregnancy induced hypertension Pharmacokinetics Magnesium sulfate Intravenous infusion
