摘要
对８名青年健康志愿者采用随机双盲交叉给药法，分别给予安慰剂、安定５ｍｇ和安定１０ｍｇ口服；于每次服药前后用自编电脑软件检测６项精神运动功能，同时进行受试者视觉模拟睡眠状态评分（ＶＡＳＳ）。结果显示：符号数字匹配测验最敏感且稳定，其结果能反映安定血药浓度变化规律，并与简单反应时间、敲指测验、视觉运动测验和ＶＡＳＳ评分结果均显著相关。
ight healthy young subjects received
single oral doses of placebo,5mg diazepam, 10mgdiazepam in a randomized double- blind
crossover study, six psychomotor performance tasksweie simultaneously determined before
administration and during the 5 hours after drug ad-ministration (0.5,1,1.5,2,3,4, 5h),the six
tasks were: digit symbol substitution task(DSST),simple reaction time task(SRTT),finger tapping
performance task(FTPT) ,memo-ry scanning task(MST),digit comparison task(DCT),and
hand-eye coordination task(HECT), meantime the volunteer visual analog sedation
scales(VASS) was also investigat-ed. The results showed that the DSST was the most sensitive
and stable psychomotor per-formance assessment method to detect the diazepam’s CNS
effects. DSST decrements weresignificantly correlated with the changes in the scores of SRTT,
FTPT, HECT, and VASS.
出处
《湖南医科大学学报》
CSCD
1995年第2期123-126,共4页
Bulletin of Hunan Medical University
基金
CMB基金
关键词
安定
精神运动性行为
药理学
diazepam
psychomotor performance
pharmacology
drug
effects
