摘要
通过观察不同治疗组的肾组织铅浓度和肾小管上皮细胞线粒体损伤数，研究碘化钾（ＫＩ）对大鼠实验性铅性肾病的治疗作用。结果显示ＫＩ在驱出肾组织铅及线粒体修复作用方面均较二疏基Ｔ－酸钠（ＤＭＳＡ）为佳，差异有高度显著性（Ｐ＜０．０１）。
Treatment effect of experimental lead nephropathy was studied. Lead
concentration ofkidney tissue and distorted mitochondria of proximaI tubule epithelial cells
have been com-pared.Lead concentration of kidney tissue of the group to treat by KI was 262μ
g/g.Thenumber of normal mitochondria was 44.5%.Lead concentration of kidnev tissue was315.
8μg/g in the group to treat by DMSA.The normal mitochondria was 19.75%(P<0.05).The results
showed that KI was better than DMSA in chelating renal lead and im-prove distorted
mitochondria of proximal tubule epithelial cells.
出处
《湖南医科大学学报》
CSCD
1995年第5期429-430,共2页
Bulletin of Hunan Medical University
基金
国家自然科学基金
关键词
碘化钾
铅中毒
肾小管
上皮细胞
线粒体
修复
lead poisoning
kidney
disease
potassium iodide
kidney tubules,proximal
ultrastructure
