摘要
报道以天然可生物降解的明胶为载体材料，蓖麻油为油相，乳化法制备硫酸链霉素肺靶向明胶微球。微球的平均容积径为９．７μｍ，平均包封率为１５．６９％，经３７℃ＲＨ７５％放置３个月，其含量、外观形态与大小基本不变，热解活化能Ｅ＝７５．８６ｋＪ／ｍｏｌ．体外释药符合Ｈｉｇｕｃｈｉ方程的规律，ｔ＿（１／２）＝８．６ｈ，家兔体内分布微球浓集于肺。
This paper is reported the technologyof lung targeting gelatin microspheres of
streptomycinsulphate(SMS).The micropheres were prepared withnatural biodegradable gelatin
as the load material andcastor oil as the oil phase。The experimental condi-tions were
optimized,the meanVolume diameter ob-tained being 9.7μm and the mean rate of
encapsulation15.69%,The content,shape and size of the micro-spheres showed no remarkable
change after storage at37C RH 75%for 3 months.Activation energy of heatdecomposition
E=75.86kJ/mol.In vitro,the SMS re-lease rate was found to accord with Higuchi equationwith
t_1/2=8.6h.In vivo(rabbits)the gelatin micro-spheres were proved to be concentrated in the
lung。
出处
《华西医科大学学报》
CSCD
1995年第2期167-171,共5页
Journal of West China University of Medical Sciences
基金
卫生部科研基金
关键词
链霉素
明胶微球
乳化法
肺靶向
Streptomycin sulphate Gelatin microspheres Emulsification method Lung
targeting Master degree graduate student Author for correspondence
