摘要
目的研究不同剂量的双环醇片治疗慢性乙型肝炎的疗效和安全性。方法随机选择62例慢性乙型肝炎病人分两组接受治疗,每日口服双环醇片150mg和75mg,观察连续用药24周后的疗效和安全性。结果两组血清氨基转移酶均得到明显下降,且150mg·d-1治疗组更为明显(P<0.01),治疗24周后两组HBeAg阴转率分别为18.8%和6.1%(P<0.01)。均未发生明显不良反应。结论双环醇片150mg·d-1治疗慢性乙型肝炎在降低血清氨基转移酶及HBeAg阴转方面优于75mg·d-1治疗,安全性好。
Objective To analyse the efficacy and reliabihty of bicyclol in different dose on the treatment of patients with chronic viral hepatitis B.Methods 62 patients with chronic viral hepatitis B were divided into two groups and received bicyclol orally 150mg daily or 75mg daily for 24 weeks. The efficacy and reliability were observed. Results Compared with pre-treatment, the serum alanine aminotransferase were decreased obviously in two groups with the bieyclol at 150 nag daily better （P 〈 0.01）. HBeAg negative conversion rate were 18.8% and 6.1% （P 〈 0.01 ）. There was no obvious adverse event. Conclusion In the terms of decreasing alanine aminotransferase level and HBeAg negative conversion, bicyclol at 150 mg daily is more effective than at 75mg daily.
出处
《实用肝脏病杂志》
CAS
2005年第4期208-209,共2页
Journal of Practical Hepatology
