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环糊精在鼻腔给药系统中的应用 被引量：13

Applications of Cyclodextrin Derivatives in Nasal Drug Delivery
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摘要 综述了环糊精作为鼻腔给药系统赋形剂的应用及安全性。 The applications and the safety of cyclodextrin derivatives as a pharmaceutical excipient used in nasal drug delivery system are reviewed.
作者 周园 刘玉玲
机构地区 中国医学科学院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2005年第8期501-504,共4页 Chinese Journal of Pharmaceuticals
关键词 环糊精 鼻腔给药 安全性 综述 cyclodextrin derivatives nasal drug delivery safety review
分类号 R944.9 [医药卫生—药剂学]
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参考文献23

  • 1Davis SS, Illum L. Absorption enhancers for nasal drug delivery[J]. Clin Pharmacokinet, 2003, 42 (13): 1107-1128.
  • 2Marttin E, Verhoef JC, Romeijn SG, et al. Acute histopathological effects of benzalkonium chloride and absorption enhancers on rat nasal epithelium in vivo [J]. Int J Pharm,1996, 141(1-2): 151-160.
  • 3Donnelly A, Kellaway IW, Taylor G, et al. Absorption enhancers as tools to determine the route of nasal absorption of peptides [J]. J Drug Target. 1997, 5 (2): 121-127.
  • 4Schipper NGM, Verhoef JC, Romeijn SG, et al. Methylated β-cyclodextrins are able to improve the nasal absorption of salmon calcitonin [J]. Calcif Tissue Int, 1995, 56 (4): 280-282.
  • 5Marttin E, Verhoef JC, Romeijn SG, et al. Effects of absorption enhancers on rat nasal epithelium in vivo: release of marker compounds in the nasal cavity [J]. Pharm Res, 1995,12(8): 1151-1157.
  • 6Marttin E, Verhoef JC, Cullander C, et al. Confocal laser scanning microscopic visualization of the transport of dextrans after nasal administration to rats: effects of absorption enhancers[J]. Pharm Res, 1997, 14(5): 631-637.
  • 7Marttin E, Verhoef JC, Spies F, et al. The effect of methylated β-cyclodextrins on the tight junctions of the rat nasal respiratory epithelium: electron microscopic and confocal laser scanning microscopic visualization studies [J]. J Controlled Release,1999, 57 (2): 205-213.
  • 8Marttin E, Verhoef JC, Merkus FWHM. Efficacy, safety and mechanism of cyclodextrins as absorption enhancers in nasal delivery of peptide and protein drugs [J]. JDrug Target, 1998,6(1): 17-36.
  • 9Yang T, Hussain A, Paulson J, et al. Cyclodextrins in nasal delivery of low- molecular-weight heparins: in vivo and in vitro studies [J]. Pharm Res, 2004, 21 (7): 1127-1136.
  • 10Matsubara K, Abe K, Irie T, et al. Improvement of nasal bioavailability of luteinizing hormone-releasing hormone agonist, buserelin, by cyclodextrin derivatives in rats [J]. J Pharm Sci, 1995, 84 (11 ): 1295-1300.

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共引文献26

同被引文献147

引证文献13

二级引证文献65

中国医药工业杂志
2005年 第8期

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