摘要
目的探讨甲状腺功能减退症(包括原发性甲减和继发性甲减)患者甲状腺功能与心肌酶的关系。方法检测了20例原发性甲减患者、20例继发性甲减患者和20例健康查体者(对照组)的空腹血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、天门冬氨酸氨基转移酶(AST)、肌酸激酶(CK)及其同工酶(CKMB)、α羟丁酸脱氢酶(HBDH)。结果原发性甲减和继发性甲减患者AST、CK、CKMB、LDH、HBDH均明显高于对照组(原发性甲减组P分别<0.01、0.01、0.05、0.05、0.01;继发性甲减组P均<0.05)。TSH及FT4与心肌诸酶无相关性,原发性和继发性甲减患者FT3均与CK、CKMB呈负相关(r分别为-0.64和-0.49,P均<0.05)。结论甲状腺功能减退症患者(包括原发性和继发性甲减)心肌酶显著升高,FT3是引起心肌酶,尤其是CK、CKMB升高的主要因素。
Objective To investigate the association between thyroid function and elevated myocardial enzymes in patients with primary and secondary hypothyroidism. Methods Aspartate aminotransferase（AST） ,creatine kinase（CK） and it＇s isoenzyme（CK-MB） , lactate dehydrogenase（LDH） and it＇s isoenzyme （ HBDH ） , free tri-iodothyronine （ FT3 ）, free thyroxin （ FT4 ） , thyrotropin （ TSH ） were measured in 20 patients with primary hypothyroidism ,20 patients with secondary hypothyroidism and 20 healthy subjects. Results We found that AST,CK, CK-MB, LDH, HBDH in both primary and sencondary hypothyroidism were all significantly higher than that in healthy subjects （ primary hypothyroidism ： P 〈 0.01,0.01,0.05,0.05,0.01 ; sencondary hypothyroidism ： P 〈 0.05 ）. In both primary and secondary hypothyroidism, TSH and FT4 had no relation with myocardial enzymes, but FT3 was negatively related with CK and CK-MB （ r = - 0. 64 and - 0. 49, both P 〈 0. 05 ）。 Conclusion All of the above suggested that myocardial enzymes were increased in patients with hypothyroidism,the lower level of FT3 was responsible for the higher levels of CK and CK-MB.
出处
《滨州医学院学报》
2005年第4期241-242,共2页
Journal of Binzhou Medical University
