摘要
目的:从微循环、器官血流量和血液流变学角度,探讨夏至草生物碱对弥散性血管内凝血(DIC)的治疗作用。方法:通过静脉注射高分子右旋糖酐Dextran500复制34只DIC大鼠模型,采用肠系膜微循环、器官微区血流量和血液流变学测定方法,观察夏至草生物碱对DIC转归时微血管口径、器官微区血流量、血黏度及血小板功能的干预作用。结果:大鼠静脉注射Dextran500后,出现了明显的微循环障碍,表现为微血管收缩、微血流变慢、微血栓形成,且血液流变性异常,表现为血黏度增高、血小板聚集性增强。夏至草生物碱治疗后微血管明显扩张,其流态和微血栓积分值均明显低于生理盐水(NS)对照组(P均<0.05),并能改善胃、肠、肝的微区血流量,效果优于NS对照组(P<0.05),全血黏度、相对黏度、血小板黏附率和聚集率也均明显低于NS对照组,红细胞变形能力则明显增强(P均<0.05)。结论:夏至草生物碱通过扩张微血管、增加器官血流量、降低血黏度和抑制血小板聚集,对DIC具有较好的治疗作用。
Objective： To investigate the therapeutic effects of alkaloids from Herba Lagopsis on blood dynamics in experimental rats with disseminated intravascular coagulation （DIC） during the recovery phase.Methods： Thirty- four rat models with DIC were replicated by injecting dextran 500. The intervention effects on diameter of microcirculation, micro - region blood flow volume of organ and platelet function were observed by the method of testing mesenteric microcirculation, micro - region blood flow volume of organ,hemorrheology and platelet function during the recovery phase of DIC. Results： After dextran 500 injection,the micro -circulatory dysfunction appeared, showing dilation of micro -blood vessels, slower micro -blood flow and micro -embolization. The abnormalities of hemorrheology showed high viscosity and increased platelet aggregative rate. Alkaloids from Herba Lagopsis could significantly dilate the micro - blood vessels.The scores of flow state and micro -embolism in alkaloids from Herba Lagopsis treatment group were significantly lower than those of normal saline （NS） control group, the micro -region blood flow volumes of stomach, intestine and liver were superior to those of NS group, and whole blood viscosity, relative viscosity,platelet adherent rate and aggregative rate were markedly lower and the deformity ability of red blood cell increased than those of the NS group. Conclusion： Alkaloids from Herba Lagopsis can efficiently treat DIC through the dilation of micro -blood vessels, increase of blood flow volume of organs, reduction of blood viscosity and platelet aggregation.
出处
《中国中西医结合急救杂志》
CAS
2005年第4期210-213,共4页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
河北省中医药中西医结合科研计划项目(20002)
关键词
弥散性血管内凝血
微循环
血流量
血液流变学
夏至草生物碱
Herba Lagopsis
disseminated intravascular coagulation
microcirculation
blood flow volume
hemorrheology
