摘要
目的:探讨肾上腺区Castleman肿瘤的临床特点及诊治方法。方法:分析肾上腺区域Castleman肿瘤患者的临床资料,临床表现为口腔和会阴溃疡、全身皮疹,皮肤活检病理示副肿瘤性天疱疮(PNP)。CT发现右肾上腺区包膜完整的肿物大小约10cm×9cm,行肿瘤切除术。并结合文献复习讨论15例Castleman肿瘤患者的临床资料。结果:术中探查见右肾上腺区域肿瘤,病理诊断右肾上腺区域巨大淋巴结增生,透明血管型,伴局灶钙化。术后随访半年,恢复良好,未见肿瘤复发,口腔及外生殖器溃疡好转,皮疹消退。天疱疮抗体滴度下降。结论:Castleman病临床上少见,表现为不明原因的淋巴结肿大。肿块可发生在淋巴组织的任何部位,肾上腺区域罕见。手术切除肿瘤为首选治疗。
Objective：To investigate the clinical features, diagnosis, and treatment of adrenal area tumor associated with Castleman disease. Methods： The patient who had adrenal area tumor associated with Castleman disease was 31 years old, admitted in our hospital with oral and perineum ulcer and skin eruption all over the body. His dermatological biopsy showed paraneoplastic pemphigus（PNP）. CT revealed a tumor with integral capsule in right adrenal area, and the tumor was incised completely. Results： The tumor in right adrenal area was found about 10cm× 9cm in size during exploration. The pathologic test showed a great hyperplastic lymph node of hyaline vascular type with local calcification. During six months follow up, the patient recovered smoothly, and no recurrence was found. His oral and perineum ulcer and skin eruption improved gradually. The level of pemphigus antibody decreased. Conclusions：Castleman disease is a rare disease, which mainly manifests swelling of lymph node with unknown cause. The tumor may occur anywhere in lymphoid tissue, especially in mediastinal cavity, neck, and axilla region, but rarely seen in adrenal area. Thus it is necessary to differentiate medullary, cortical, or retroperitoneal origination for the tumor located in adrenal area. Other rare tumor should also be considered at the same time.Surgical excision of tumor is the preferred therapeutic choice.
出处
《临床泌尿外科杂志》
2005年第8期453-454,共2页
Journal of Clinical Urology
