摘要
目的:了解肾综合征出血热(HFRS)患者不同病期和病型TNF-α动态变化。方法:用ELISA检测32例HFRS患者血清TNF-α含量。结果:在不同病期的HFRS患者中,TNF-α在发热期已升高,低血压期明显升高,至少尿期达到高峰。在不同病型的HFRS患者中,随病情加重,TNF-α的含量与尿蛋白水平呈正相关。结论:动态检测HFRS患者血清TNF-α含量,对病情进展和疾病严重程度的判断有一定意义。
Objective： To investigate the dynamic changes of tumor necrosis factor-α（TNF-α） in serum of patients with hemorrhagic fever with renal syndrome（HFRS） from different phases and clinical types of the disease. Methods： The serum level of TNF-α was rneasured by ELISA in 32 subjects hospitalized with HFRS. Results： For different phase of HFRS, the levels of TNF-α started to increase in febrile phase, increased significantly in hypotensive phase and reached its peak in oliguric phase. For different clinical type of HFRS, with the aggravation of the subjects＇conditions, the levels of TNF-α increased accordingly. Especially in those subjects of grave syndrome, the level of TNF-α increased persistently.In addition, there was a positive correlation between the level of TNF-α and the level of urinary protein.Conclusion： Dynamic detection of TNF-α may play an important role in evaluating the progression and severity of HFRS.
出处
《西南国防医药》
CAS
2005年第4期363-366,共4页
Medical Journal of National Defending Forces in Southwest China
关键词
肾综合征出血热
Α-肿瘤坏死因子
tumor necrosis factor-α, hemorrhagic fever with renal syndrome, diagnosis, prognosis
