摘要
①目的分析初治肺结核病人外周血中干扰素-γ(IFN-γ)和白细胞介素-12(IL-12)在2个月强化治疗后的变化,探讨肺结核细胞免疫机制,提高临床治疗水平。②方法随机选择初治肺结核病人38例,正常对照者23例,用酶联免疫吸附(ELISA)法测定结核病人强化治疗前后和正常对照组外周血中IFN-γ和IL-12的含量。③结果初治肺结核病人治疗前外周血中IFN-γ和IL-12含量明显低于正常对照组(t=9.20、4.70,P<0.001),治疗后与正常对照组比较无显著性差异(t=0.31、1.30,P>0.05);治疗组强化治疗前、后外周血中IFN-γ和IL-12的含量差异有显著性(t=4.30、7.50,P<0.01)。④结论初治肺结核病人早期Th1反应明显占优势,2个月强化期治疗后恢复到正常人水平。
Objective To analyze the changes of interferon type Ⅱ （IFN-γ） and interleikin-12 （IL-12） in the peripheral blood of initially-treated patients with pulmonary tuberculosis before and after two months intensification treatment, and to explore the cell-mediated immunity mechanism and to improve clinical therapy. Methods Thirty-eight patients with initial pulmonary tuberculosis and 23 normal controls were randomly selected. The contents of IL-12 and IFN-γ in the peripheral blood of the patients,before and after reinforcement anti-tuberculosis therapy, and of the controls were detected by enzyme-linked immunosorbent assay（ELISA）. Results The contents of IL-12 and IFN-γ of the patients before the treatment were markedly lower than those of the controls （t=9.20,4.70; P〈0. 001）, but no significant difference was noted after treatment （t=0.31,1.30 ； P〉0.05）. The difference of the contents of IL-12 and IFN-γ before and after the treatment was significant （t=4.30,7.50;P〈0.01）. Conclusion The Th1 reactivity in the initial patients with pulmonary tuberculosis is strong in early period, but returns to normal level after two months of intensification anti-tuberculosis therapy.
出处
《青岛大学医学院学报》
CAS
2005年第2期161-162,共2页
Acta Academiae Medicinae Qingdao Universitatis
关键词
干扰素Ⅱ型
白细胞介素12
结核
肺
治疗结果
interferon type Ⅱ
interleukin-12
tuberculosis, pulmonary
treatment outcome
