期刊文献+

免疫衰老及其免疫学预警指标 被引量:19

下载PDF
导出
摘要 增龄导致胸腺萎缩,成为免疫衰老的直接原因。免疫衰老是免疫系统全方位多系统的并由基因严格控制的循序渐进的自然过程,在这一过程中,免疫系统发生了许多明显的变化,细胞免疫、体液免疫以及天然免疫均有不同程度的改变。免疫学预警指标(immunologicalriskphenotypes,IRP),不仅可以评价机体的免疫状态,而且可以提前预知疾病的发生,为免疫干预提供客观数据。
出处 《现代免疫学》 CAS CSCD 北大核心 2005年第4期347-349,共3页 Current Immunology
  • 相关文献

参考文献26

  • 1Romanyu-kha AA, Yashin AI. Age related changes in population of peripheral T cells: towards a model of immunosenescence[J].Mech Ageing Dev, 2003,124:433-443.
  • 2Ginaldi L, Loreto MF, Corsi MP, et al. Immunosenescence and infectious diseases[J]. Microbes Infect, 2001,3:851-857.
  • 3Fagnoni FF, Vescovini R, Passeri G, et al. Shortage of circulating naive CD8^+ T cells provide new insights on immunodeficiency in aging[J]. Blood, 2000,95:2860-2868.
  • 4Leng Q, Bentwich Z, Borkow G. CTLA-4 upregulation during aging[J]. Mech Ageing Dev, 2002,123(10):1419-1421.
  • 5Niedermuller H, Basota I, Strasser A, et al. Age dependence of signal transduction and cell signting as a major factor of intervention into the aging process[J]. Arch G erontol Geriat, 2001,33:151-161.
  • 6Sudhir-Gupta MD. A role of inhibitor of apoptosis(IAP) proteins in increased lymphocyte apoptosis in aged humans[J]. Mech Ageing Dev, 2004,125:99-101.
  • 7Zanni F, Vescovini R, Biasini C, et al. Marked increase with age of type 1 cytokines within memory and effeotor/cytotoxic CD8^+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence[J]. Exp Gerontol,2003,38: 981-987.
  • 8Ouyang Q, Wagner WM, Walter S, et al. An age-related increase in the number of CD8(+) T cells carrying receptors for an immunodominant Epstein-Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness[J].Mech Ageing Dev, 2003,124:477-485.
  • 9Ginaldi L, De Martinis M, D'Ostilio A,et al. Changes in the expression of surface receptors on lymphocyte subsets in the elderly: a quantitative flow cytometric analysis[J]. Am J Hematol,2001,67:63-72.
  • 10Sudhir-Gupta MD. P-glycoprotein expression in the cells of the immune system during aging[J]. Clin Appl Immunol, 2003,4:59-70.

同被引文献186

引证文献19

二级引证文献146

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部