摘要
目的探讨盖诺加顺铂治疗蒽环类耐药晚期乳腺癌的临床应用效果和护理配合。方法蒽环类耐药的晚期乳腺癌52例患者,采用盖诺(NVB)25mg/m2ivgtt·d1,8,顺铂(PDD)30mg/m2,ivgtt.d1～3,21天为1周期,2周期评价疗效,全组化疗共175周期,每例平均3个周期(2～5周期)。结果部分缓解率(PR)42.3%(22/52),无完全缓解患者;生活质量有改善,治疗后Karnofsky评分(77.5±16.6)高于治疗前(69.5±21.5),P>0.05。不良反应主要为白细胞降低86.5%,恶心呕吐59.6%和外周静脉炎30.8%等。结论盖诺加顺铂治疗蒽环类耐药的晚期乳腺癌作为二线化疗,护理人员应做好护理,促进患者康复,观察化疗后患者的反应,保证化疗的顺利进行。
Objective To explore the clinical effects and nursing of vinorelbine combined with cisplatin regimen on the breast cancer patients with anthracycline- resistant. Methods 52 breast cancer patients with anthracycline-resistant were treated with combination chemotherapy of vinorelbine 25mg/m^2d1,8 iv and cisplatin 30mg/m^2 d1-3 iv given every 21 days. A total of 175 cycles were administered. Averagely each patient received 3 cycles. Results The partial response （PR） was 42.3%, there was no complete response. Additionally, the quality of patients＇ life improved. The karnofsky mark after treatment （77.5-16.6）was higher than before（69.5-21.5）（p〉0.05）. The main side effects were that leukopenia was 86.5 %. Nausea/vomiting was 59.6 % and periphlebitis was 30.8%. Conclusions The results of this study shows that vinorelbine combining with cisplatin regimen can be used as the second-line therapy for relapsed advanced breast cancer, to which nurse should pay more attention in order to help patients recovery and observe the patients＇ reaction after chemotherapy to ensure smooth treatment.
出处
《现代护理》
2005年第13期1045-1046,共2页
Modern Nursing
关键词
盖诺
顺铂
乳腺癌
蒽环类药物
护理
Breast cancer Vinorelbine Cisplatin Anthracycline Nursing
