摘要
目的:调查抗抑郁药物治疗过程中出现转相的几率。方法:按照抗抑郁药物引起躁狂、轻躁狂、快速循环的定义,对321例接受抗抑郁治疗的病人出现躁狂、轻躁狂、快速循环进行调查、分析、比较。结果:321例中, 共有51例病人在治疗过程中转相,总发生率或转躁率为15．9％;171例单次发作抑郁和反复发作抑郁的转躁率 5．8％;150例双相障碍中,由抗抑郁药物引发的转躁例数41例,转躁率34％,比单相病人的转躁率,差异具有显著性(x2=27．60,P<0．001);98例以抑郁首发的双相障碍病人中,有37例病人出现转相,转躁率37．7％,52例以躁狂首发的双相障碍,在随后出现抑郁而进行抗抑郁治疗过程中,有4例病人出现药物性躁狂或轻躁狂,转躁率为 7．7％,这种以不同症状首发的双相障碍出现的转躁率差异显著(x2=15．548,P<0．01)。结论:抗抑郁药物治疗过程中,一部分病人会出现转躁,尤以双相障碍病人为明显。
Objective： To investigate the prevalence of switching rate associated with antidepressants, Method： The switching rate during therapy with antidepressants in 321 cases was investigated and analyzed according to the definition of mania, hypomania and rapid cycling induced by antidepressants. Result： 51 cases of mania, hypomania and rapid cycling induced by antidepressants in 321 patients treated with antidepressants were diagnosed, and its switching rate was 15.9%, The switching rate of 171 cases with the first episode of depression and with the recurrent depression was 5.8%, The switching rate of 150 patients with bipolar disorders was 34% , which was significantly higher than that of unipolar depression （x^2 = 27.60 ,P 〈 0. 001 ）. 37 cases of mania, hypomania and rapid cycling induced by antidepressants in 98 bipolar patients with the first episode of depression were diagnosed, its switching rate being 37.7%. 4 cases of mania, hypomania and rapid cycling induced by antidepressants in 52 bipolar patients with first episode of mania were diagnosed, its switching rate being 7.7% , significantly lower than that of patients with the first episode of depression（x^2= 15. 548 ,P 〈0.01 ）. Conclusion： Some patients treated with antidepressants maybe switch to mania, hypomania , or rapid cycling, especially bipolar depressiou.
出处
《药物流行病学杂志》
CAS
2005年第4期217-219,共3页
Chinese Journal of Pharmacoepidemiology
基金
浙江省卫生厅重点扶持学科项目(2004011)
关键词
抗抑郁药物
抑郁症
转相
临床流行病学
药物不良反应
Antidepressants
Depression
Switching
Clinical epidemiology
Adverse drug reaction
