摘要
目的观察机械通气时新生儿血清铁蛋白(SF)的变化,探讨其在呼吸机诱发肺损伤(VILI)中的临床意义。方法使用机械通气的新生儿36例为机械通气组,未使用机械通气的新生儿31例为非机械通气组。机械通气组在机械通气后12、4、487、2 h和撤机后24 h采集静脉血,非机械通气组在同样时段采集静脉血,用放射免疫方法检测SF。结果机械通气组SF水平明显升高,与非机械通气组比较差异有显著性(P<0.05),且升高程度与使用机械通气天数呈显著相关性(r=0.431 P=0.011)。机械通气后48 h SF水平出现明显变化,且持续在高水平上波动,随着病情好转撤机,SF水平逐渐回落,提示机械通气后48 h患儿可能开始出现肺损伤。结论动态观察新生儿机械通气时SF水平可能有助于监测VILI的发生,指导临床诊治。
Objective To observe the changes of serum ferritin （SF）in neonates with mechanical ventilation and its clinical significance in the ventilation induced lung injury （VILI）. Methods The study was carried out in 36 neonates with mechanical ventilation and 31 neonates without mechanical ventilation in neonate intensive care unit （NICU）. SF level in venous blood was measured on 1,24,48,72 hours after mechanical ventilation and 24 hours after mechanical ventilation removal by radioinmmunoassay （RIA）. SF level of non-mechanical ventilation group were detemined at the santo time. Results SF levels in mechanical ventilation groups were significantly higher than those of control group （P〈0.05）, SF level were significantly correlated with the use of mechanical ventilation and the days requiring mechanical ventilation（r=0.431 P=0.011 ）. SF level in neonates on 48 hours after mechanical ventilation was obviously elevated, SF level was prolonged elevation after mechanical ventilation. Conclusion Evaluating SF in neonates after mechanical ventilation may help monitor the development and guid the clinical diagnosis and treatment of VILI.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2005年第8期738-740,共3页
Journal of Applied Clinical Pediatrics
基金
兰州市自然科学基金项目资助(02-1-27)
关键词
婴儿
新生
通气机
机械
肺损伤
铁蛋白
infant, newborn
ventilators mechanical
lung injury
ferritin
