摘要
在0.2mol/L KH2PO4-Na2HPO4(pH5.5±0.1)支持电解质中,奥沙普秦产生一催化氢波,峰电位Ep＝-1.25V(vs.SCE).当1×10-2mol/LH2O2存在时,该催化氢波的峰电流增加12倍,峰电位基本不变,产生一较灵敏的平行催化氢波.其二阶导数峰峰电流ip″与奥沙普秦浓度在1.0×10-7～2.6×10-5mol/L范围内呈线性关系(r＝0.9995,n＝10),检出限为5.0×10-8mol/L.该方法可用于药物制剂中奥沙普秦含量的测定.
A catalytic hydrogen wave of oxaprozin appears at ca.-1.25（vs. SCE）in 0. 2mol/L KH2PO4-Na2HPO4（pH5. 5±0.1）supporting electrolyte. When 1×10^-2mol/L H2O2 is present, the peak current of the catalytic hydrogen wave increases by 12 times,and the peak petentioal is unchanged,producing a more sensitive parallel catalytic hydrogen wave. The second-order different peak current of the parallel catalytic hydrogen wave is rectilinear to oxaprozincon centration in the range 1.0×10^-7～2.6×10^-5mol/L（r =0.9995 ,n=10）. The detection limit is 5.0×10^-8mol/L. The proposed method can be applied to the determination of oxaprozin in pharmaceuticals without preliminary separation.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2005年第4期460-463,共4页
Chemical Research and Application
基金
国家自然科学基金资助项目(29875017)
关键词
奥沙普秦
过氧化氢
催化氢波
平行催化氢波
单扫描示波极谱法
oxaprozin
hydrogen peroxide
catalytic hydrogen wave
parallel catalytic hydrogen wave
single sweep polarography
