摘要
对３２例无先兆型偏头痛的男性飞行员进行血浆血管紧张素Ⅱ（ＡＴＤ－Ⅱ）、强啡肽（ＤＹＮＡ）、Ｐ物质（ＳＰ）、６－酮前列环素（６－ｋｅｔｏ－ＰＧＦ１）、血栓素Ｂ２（ＴＸＢ２）含量的测定，并与３０例健康飞行员对照。结果显示偏头痛组血浆ＡＴ－Ⅱ、ＴＸＢ２升高，６－ｋｅｔｏ－ＰＧＦ１降低，发作期ＤＹＮＡ降低，ＳＰ升高，与对照组比较均Ｐ＜０．０５或０．０１，而间歇期ＤＹＮＡ、ＳＰ无变化。表明偏头痛发作与神经内分泌失调有关，ＡＴ－Ⅱ升高提示肾素－血管紧张素系功能亢进；ＳＰ升高，ＤＹＮＡ降低提示与痛阈降低和对疼痛敏感有关；ＴＸＢ２升高、６－ｋｅｔｏ－ＰＧＦ１．降低表明其血管、血小板功能异常。
Contents of plasma angiotensin(AT-Ⅱ) , dynorphin A(DYNA ) , SP,6-keto-PGF1 andTXB2 were determined in 32 male fighter pilots with migraine with no premonitory symptoms, and werecompared with those in 30 healthy pilots。 The results showed that the contents of plasma AT-Ⅱ and TXB2increased while the content of 6-keto-PGF1 decreased。 During the attack of migraine, the content of SPincreased while the content of DYNA decreased,P<0. 05 or P<0. 01 as compared with that of the normalcontrol group, no change was found in DYNA and in SP at intervals。 The authorsl conclusion is as fol-lows : the attack of rnigraine is associated with neural endocrine disorders : increase of AT-Ⅱ means hyper-function of the renin-angiotensin system; increase of SP and decrease of DYNA suggest attack of migrainernay be related with the reduction of pain threshold and sensitivity to pain; increase of TXB2 and decreaseof 6-keto-PGF1 show the function of blood vessels and platelets of patients with migraine is abnormal。
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1995年第2期105-107,共3页
Medical Journal of Chinese People's Liberation Army
关键词
飞行员
偏头痛
神经递质和调质
Pilot
Migraine
Neurotransmitter and modulator
