摘要
目的探讨神经胶质瘤组织中Ki-67抗原表达及其与肿瘤发生和恶性程度的关系。方法应用免疫组化Envision法对39例颅内神经胶质细胞瘤标本中Ki-67抗原的表达进行检测,观察Ki-67与神经肿瘤恶性程度间的关系。结果不同恶性程度胶质细胞瘤间Ki-67表达强度有明显差异(F=36.375,P<0.05),与肿瘤的恶性程度呈正相关(r=0.939,P<0.05)。结论细胞增殖核抗原Ki-67的表达与胶质瘤的发生及其恶性程度有一定关系,临床检测Ki-67指数有助于患者预后评估。
Objective To explore the Ki-67 expression in human gliomas and its implication to tumorigenesis and the degree of gliomas＇ malignancy. Methods After Ki-67 antigen expression in 39 gliomas were determined hy immunohistochemica] technique, we evaluate the relation Ki-67 expression and the one between the degree of gliomas＇ malignancy. Results The expression of ki-67 antigen were significantly different （P〈36.375, P〈0.05）, and had a positive correlation with the malignant degrees （r=0.939, P〈0. 050）. Conclusions The expression Ki-67 antigen could be related to the tumorigenesis and the degrees of malignancy of human brain gliomas. The Ki-67 L1 detected will provide more useful infonmation for patient＇s prognosis.
出处
《国际医药卫生导报》
2005年第16期13-14,共2页
International Medicine and Health Guidance News
